Thesis (Ph.D)-Cairo University, 2023.

Bibliography: pages 140-162.

Background: Assisted Reproductive Technologies were first developed nearly four
decades ago to aid in reducing the burden of infertility. Today, Assisted Reproductive
Technologies is accountable for greater than 4 percent of all live births. While most of
Assisted Reproductive Technologies-born infants are healthy, concerns about the
health of Assisted Reproductive Technologies born infants have emerged recently.
There is an elevated risk of perinatal negative outcome in newborns conceived by
Assisted Reproductive Technologies. Purpose: The purpose of this study was to
compare the neurobehavior and maturity of singleton neonates conceived through
fresh and frozen embryo transfer with those through naturally conceived. Methods:
This study included186 singleton neonates whose mothers age ranged from 25 to 35
years old with their body mass index ranged from 18.5 to 29 and they were born
through in vitro fertilization/ intra cytoplasmic injection (frozen embryo transfer and
fresh embryo transfer) following 37 weeks of gestation were enrolled in this study.
Singleton neonates conceived without fertility treatments (natural conceived) served
as a reference group. They were equally distributed into three groups: Group A: 62
Naturally conceived singleton neonates, Group B: 62 singleton neonates conceived
from fresh embryo transfer and Group C: 62 singleton neonates conceived from
frozen embryo transfer. Singleton neonates in each three groups were assessed for
behavior by Brazelton Neonatal Behavioral Assessment Scale and for maturity by
New Ballard Score. Results: The Brazelton and New Ballard score demonstrated
significant differences between three groups P values <0.05. Conclusion: The
neurobehavior of singleton neonates conceived from naturally conceived are better
than that of fresh and frozen embryo transfer and the estimated gestational age was
lowest in fresh embryo transfer in comparison with both frozen embryo transfer and
normal conceived and it was lower in normal conceived compared to frozen embryo
transfer.

شملت الدراسة ١٨٦ مولود فردي لاجنة حديثة ومجمدة وحمل طبيعي، تم توزيع المواليد الذين تم ولادتهم بعد ٣٧ أسبوع وعمر أمهاتهم يتراوح بين ٢٥ الي ٣٥ سنة و معدل كتلة الجسم للامهات يتراوح من١٨,٥ الي ٢٩ علي ثلاثة مجموعات .المجموعة ا :٦٢ مولود فردي ناتج عن حمل طبيعي المجموعة ب : ٦٢مولود فردي ناتج من اجنة حديثة ⸲ المجموعة ج : ٦٢ مولود فردي ناتج من اجنة مجمدة. كل مولود في الثلاث مجموعات تم تقييمه بمقياس "برازيلتون" لتقييم السلوك العصبي ومقياس "بالرد" الحديث لتقييم النضج . السلوك العصبي للمولود الناتج عن الحمل الطبيعي افضل من الناتج عن الاجنة الحديثة و المجمدة و عمر الحمل التقريبي في المولود الفردي الناتج من اجنة حديثة اقل من الناتج عن الاجنة المجمدة و حمل طبيعي و اقل في المولود الناتج من حمل طبيعي مقارنة بالاجنة المجمدة

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Text in English and abstract in Arabic & English.