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Effect of ultrasound cavitation on insulin resistance in patients with central obesity in female / by Aya Saeed Khalil Shazly ; Supervisors Prof. Dr. Maher Ahmed El Keblawy, Prof. Dr. Magda Gaid Sedhom, Prof. Dr. Hanan Mohamed El Tokhy, Dr. Ayah Mahmoud Mohamed.

By: Contributor(s): Material type: TextLanguage: English Summary language: English, Arabic Producer: 2025Description: 108 pages : illustrations ; 25 cm. + CDContent type:
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  • تأثير الموجات فوق الصوتية التجويفيه على مقاومة الأنسولين لدى مرضى السمنة المركز [Added title page title]
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Dissertation note: Thesis (Ph.D)-Cairo University, 2025. Summary: Background: Central obesity significantly contributes to insulin resistance and associated metabolic disorders. Non-invasive approaches such as ultrasound cavitation have emerged as potential treatments for reducing localized fat and improving metabolic health. Objective: The purpose of this study was to investigate the effect of ultrasound cavitation on insulin resistance (IR), skin fold thickness and Waist hip ratio (WHR), in patients with abdominal central obesity. Design of the study: This randomized controlled trial included 52 females aged 25-40 years with central obesity, divided randomly into two equal groups. Experimental group (A) received ultrasound cavitation for 6 weeks, aerobic exercises, and a low-calorie diet for 12 weeks, while control group (B) received only aerobic exercises and a low-calorie diet for 12 weeks. Outcomes included Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), abdominal skinfold thickness and WHR, assessed before and after a 12-week intervention. Results: There was a significant reduction in all measured variables in group (A) than Group (B). It was used to measure the weight and height for all patients before starting the assessment. (p < 0.05). Group (A) showed reductions of 23% in HOMA-IR, 7% in abdominal skinfold thickness, and 8% in waist-hip ratio. In contrast, group (B) demonstrated less reductions of 5%, 0.5%, and 0.7%, respectively. Conclusion: Ultrasound cavitation, combined with exercise and low-calorie diet, significantly improves insulin resistance and central obesity markers. This approach offers promising non-invasive treatment for managing central obesity and its complications.Summary: الخَلْفِيَّةُ: تُعَدُّ السِّمْنَةُ المَرْكَزِيَّةُ مِنَ العَوامِلِ الرَّئِيسِيَّةِ المُسَاهِمَةِ فِي الإِصَابَةِ بِمُقَاوَمَةِ الإِنْسُولِينِ وَالاضْطِرَابَاتِ الأَيضِيَّةِ المُرْتَبِطَةِ بِهَا. وَقَدْ ظَهَرَت تِقْنِيَاتٌ غَيْرُ جِرَاحِيَّةٍ مِثْلَ العِلَاجِ بِالْمَوْجَاتِ فَوْقَ الصَّوْتِيَّةِ التَّجْوِيفِيَّةِ كَعِلَاجَاتٍ وَاعِدَةٍ لِتَقْلِيلِ الدُّهُونِ المَوْضِعِيَّةِ وَتَحْسِينِ الصِّحَّةِ الأَيضِيَّةِ. هَدَفُ الدِّرَاسَةِ: هَدَفَتْ هَذِهِ الدِّرَاسَةُ إِلَى التَّحَقُّقِ مِنْ تَأْثِيرِ تِقْنِيَةِ العِلَاجِ بِالْمَوْجَاتِ فَوْقَ الصَّوْتِيَّةِ التَّجْوِيفِيَّةِ عَلَى مُؤَشِّرِ مُقَاوَمَةِ الإِنْسُولِينِ (HOMA-IR)، وَسُمكِ طِيَّةِ الجِلْدِ، وَنِسْبَةِ مُحِيطِ الخَصْرِ إِلَى الوِرْكِ لَدَى الإِنَاثِ اللَّوَاتِي يُعَانِينَ مِنَ السِّمْنَةِ البَطْنِيَّةِ المَرْكَزِيَّةِ. المَنْهَجِيَّةُ: شَمِلَتْ هَذِهِ الدِّرَاسَةُ العَشْوَائِيَّةُ المُحَكَّمَةُ (52) سَيِّدَةً تَتَرَاوَحُ أَعْمَارُهُنَّ بَيْنَ (25–40) عَامًا، مُصابَاتٍ بِالسِّمْنَةِ المَرْكَزِيَّةِ، حَيْثُ تَمَّ تَقْسيمُهُنَّ عَشْوائِيّاً إِلى مَجْمُوعَتَيْنِ مُتَساوِيَتَيْنِ: المَجْمُوعَةُ التَّجْريبِيَّةُ (أ) تَلَقَّتِ الكافِيتِيشِن بِالمَوْجاتِ فَوْقَ الصَّوْتِيَّةِ، وَالتَّمارينَ الهَوائِيَّةَ، وَنِظاماً غِذائِيّاً مُنْخَفِضَ السُّعْراتِ الحَرارِيَّةِ، بَيْنَما المَجْمُوعَةُ الضّابِطَةُ (ب) تَلَقَّتِ التَّمارينَ الهَوائِيَّةَ وَالنِّظامَ الغِذائِيَّ مُنْخَفِضَ السُّعْراتِ فَقَط. وَقَدْ شَمِلَتِ القِياسَاتُ: مُؤَشِّرَ مُقاوَمَةِ الإِنْسُولين (HOMA-IR)، وَسُمْكَ طَيَّةِ الجِلْدِ البَطْنِيَّةِ، وَنِسْبَةَ الخَصْرِ إِلى الوِرْكِ، وَذلِكَ قَبْلَ وَبَعْدَ التَّدَخُّلِ الَّذِي اسْتَمَرَّ (12) أُسْبُوعاً. النَّتَائِجُ: أَظْهَرَتِ المَجْمُوعَةُ التَّجْريبِيَّةُ (أ) انْخِفاضاً مَعْنَوِيّاً فِي جَميعِ المُتَغَيِّراتِ المَقيسَةِ مُقارَنَةً بِالمَجْمُوعَةِ الضّابِطَةِ (ب) (p < 0.05)، حَيْثُ انْخَفَضَ مُؤَشِّرُ HOMA-IR بِمِقْدارِ (23%)، وَسُمْكُ طَيَّةِ الجِلْدِ البَطْنِيَّةِ بِمِقْدارِ (7%)، وَنِسْبَةُ الخَصْرِ إِلى الوِرْكِ بِمِقْدارِ (8%). فِي المُقابِلِ، أَظْهَرَتِ المَجْمُوعَةُ الضّابِطَةُ (ب) انْخِفاضاتٍ أَقَلَّ بَلَغَتْ (5%) فِي HOMA-IR، وَ(0.5%) فِي طَيَّةِ الجِلْدِ، وَ(0.7%) فِي نِسْبَةِ الخَصْرِ إِلى الوِرْكِ. الاِسْتِنْتَاجُ: ظْهِرُ العِلَاجُ بِالْمَوْجَاتِ فَوْقَ الصَّوْتِيَّةِ التَّجْوِيفِيَّةِ، عِنْدَ دَمْجِهِ مَعَ التَّمَارِينِ الرِّيَاضِيَّةِ وَالنِّظَامِ الغِذَائِيِّ، فَعَّالِيَّةً وَاضِحَةً فِي تَحْسِينِ مُؤَشِّرِ مُقَاوَمَةِ الإِنْسُولِينِ، وَيُعَدُّ هَذَا النَّهْجُ عِلَاجًا وَاعِدًا غَيْرَ جِرَاحِيٍّ لِإِدَارَةِ السِّمْنَةِ المَرْكَزِيَّةِ وَمُضَاعَفَاتِهَا.
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Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.21.09.Ph.D.2025.Ay.E (Browse shelf(Opens below)) Not for loan 01010110093402000

Thesis (Ph.D)-Cairo University, 2025.

Bibliography: pages 84 -250.

Background: Central obesity significantly contributes to insulin resistance and associated metabolic disorders. Non-invasive approaches such as ultrasound cavitation have emerged as potential treatments for reducing localized fat and improving metabolic health. Objective: The purpose of this study was to investigate the effect of ultrasound cavitation on insulin resistance (IR), skin fold thickness and Waist hip ratio (WHR), in patients with abdominal central obesity. Design of the study: This randomized controlled trial included 52 females aged 25-40 years with central obesity, divided randomly into two equal groups. Experimental group (A) received ultrasound cavitation for 6 weeks, aerobic exercises, and a low-calorie diet for 12 weeks, while control group (B) received only aerobic exercises and a low-calorie diet for 12 weeks. Outcomes included Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), abdominal skinfold thickness and WHR, assessed before and after a 12-week intervention. Results: There was a significant reduction in all measured variables in group (A) than Group (B). It was used to measure the weight and height for all patients before starting the assessment. (p < 0.05). Group (A) showed reductions of 23% in HOMA-IR, 7% in abdominal skinfold thickness, and 8% in waist-hip ratio. In contrast, group (B) demonstrated less reductions of 5%, 0.5%, and 0.7%, respectively. Conclusion: Ultrasound cavitation, combined with exercise and low-calorie diet, significantly improves insulin resistance and central obesity markers. This approach offers promising non-invasive treatment for managing central obesity and its complications.

الخَلْفِيَّةُ: تُعَدُّ السِّمْنَةُ المَرْكَزِيَّةُ مِنَ العَوامِلِ الرَّئِيسِيَّةِ المُسَاهِمَةِ فِي الإِصَابَةِ بِمُقَاوَمَةِ الإِنْسُولِينِ وَالاضْطِرَابَاتِ الأَيضِيَّةِ المُرْتَبِطَةِ بِهَا. وَقَدْ ظَهَرَت تِقْنِيَاتٌ غَيْرُ جِرَاحِيَّةٍ مِثْلَ العِلَاجِ بِالْمَوْجَاتِ فَوْقَ الصَّوْتِيَّةِ التَّجْوِيفِيَّةِ كَعِلَاجَاتٍ وَاعِدَةٍ لِتَقْلِيلِ الدُّهُونِ المَوْضِعِيَّةِ وَتَحْسِينِ الصِّحَّةِ الأَيضِيَّةِ.
هَدَفُ الدِّرَاسَةِ: هَدَفَتْ هَذِهِ الدِّرَاسَةُ إِلَى التَّحَقُّقِ مِنْ تَأْثِيرِ تِقْنِيَةِ العِلَاجِ بِالْمَوْجَاتِ فَوْقَ الصَّوْتِيَّةِ التَّجْوِيفِيَّةِ عَلَى مُؤَشِّرِ مُقَاوَمَةِ الإِنْسُولِينِ (HOMA-IR)، وَسُمكِ طِيَّةِ الجِلْدِ، وَنِسْبَةِ مُحِيطِ الخَصْرِ إِلَى الوِرْكِ لَدَى الإِنَاثِ اللَّوَاتِي يُعَانِينَ مِنَ السِّمْنَةِ البَطْنِيَّةِ المَرْكَزِيَّةِ.
المَنْهَجِيَّةُ: شَمِلَتْ هَذِهِ الدِّرَاسَةُ العَشْوَائِيَّةُ المُحَكَّمَةُ (52) سَيِّدَةً تَتَرَاوَحُ أَعْمَارُهُنَّ بَيْنَ (25–40) عَامًا، مُصابَاتٍ بِالسِّمْنَةِ المَرْكَزِيَّةِ، حَيْثُ تَمَّ تَقْسيمُهُنَّ عَشْوائِيّاً إِلى مَجْمُوعَتَيْنِ مُتَساوِيَتَيْنِ: المَجْمُوعَةُ التَّجْريبِيَّةُ (أ) تَلَقَّتِ الكافِيتِيشِن بِالمَوْجاتِ فَوْقَ الصَّوْتِيَّةِ، وَالتَّمارينَ الهَوائِيَّةَ، وَنِظاماً غِذائِيّاً مُنْخَفِضَ السُّعْراتِ الحَرارِيَّةِ، بَيْنَما المَجْمُوعَةُ الضّابِطَةُ (ب) تَلَقَّتِ التَّمارينَ الهَوائِيَّةَ وَالنِّظامَ الغِذائِيَّ مُنْخَفِضَ السُّعْراتِ فَقَط. وَقَدْ شَمِلَتِ القِياسَاتُ: مُؤَشِّرَ مُقاوَمَةِ الإِنْسُولين (HOMA-IR)، وَسُمْكَ طَيَّةِ الجِلْدِ البَطْنِيَّةِ، وَنِسْبَةَ الخَصْرِ إِلى الوِرْكِ، وَذلِكَ قَبْلَ وَبَعْدَ التَّدَخُّلِ الَّذِي اسْتَمَرَّ (12) أُسْبُوعاً.
النَّتَائِجُ: أَظْهَرَتِ المَجْمُوعَةُ التَّجْريبِيَّةُ (أ) انْخِفاضاً مَعْنَوِيّاً فِي جَميعِ المُتَغَيِّراتِ المَقيسَةِ مُقارَنَةً بِالمَجْمُوعَةِ الضّابِطَةِ (ب) (p < 0.05)، حَيْثُ انْخَفَضَ مُؤَشِّرُ HOMA-IR بِمِقْدارِ (23%)، وَسُمْكُ طَيَّةِ الجِلْدِ البَطْنِيَّةِ بِمِقْدارِ (7%)، وَنِسْبَةُ الخَصْرِ إِلى الوِرْكِ بِمِقْدارِ (8%). فِي المُقابِلِ، أَظْهَرَتِ المَجْمُوعَةُ الضّابِطَةُ (ب) انْخِفاضاتٍ أَقَلَّ بَلَغَتْ (5%) فِي HOMA-IR، وَ(0.5%) فِي طَيَّةِ الجِلْدِ، وَ(0.7%) فِي نِسْبَةِ الخَصْرِ إِلى الوِرْكِ.
الاِسْتِنْتَاجُ: ظْهِرُ العِلَاجُ بِالْمَوْجَاتِ فَوْقَ الصَّوْتِيَّةِ التَّجْوِيفِيَّةِ، عِنْدَ دَمْجِهِ مَعَ التَّمَارِينِ الرِّيَاضِيَّةِ وَالنِّظَامِ الغِذَائِيِّ، فَعَّالِيَّةً وَاضِحَةً فِي تَحْسِينِ مُؤَشِّرِ مُقَاوَمَةِ الإِنْسُولِينِ، وَيُعَدُّ هَذَا النَّهْجُ عِلَاجًا وَاعِدًا غَيْرَ جِرَاحِيٍّ لِإِدَارَةِ السِّمْنَةِ المَرْكَزِيَّةِ وَمُضَاعَفَاتِهَا.

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