Expression of TLR 2 And 4 and The Detection of HHV6,7 in cutaneous lesions of pityriasis rosea / Nadine Hamada Moustafa ; Supervised Eman Shaarawy , Laila Rashed , Marwa Mohamed Fawzy

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Nadine Hamada Moustafa

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TextLanguage: English Publication details: Cairo : Nadine Hamada Moustafa , 2013Description: 125 P. : charts , facsimiles ; 25cmOther title:

الكشف عن ظهورمستقبلات التول 2 ,4 والكشف عن فيروس الهيربس (6,7) في الاصابات الجلدية لمرض النخالة الوردية [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Verneroloy Summary: Pityriasis rosea (PR) is a common papulosquamous skin disease in which infective agent may be implicated. Reactivation of human herpes virus 7 (HHV-7) and, in some cases human herpes virus 6 (HHV-6) was suggested to occur in PR. The aim of this study is to detect the possibility of HHV 6,7 involvement in the pathogenesis of PR and it's relation with TLRs 2,4. In our study 25 PR patients, and 25 healthy controls were recruited, a skin biopsy from PR lesions was obtained and real-time PCR was performed to measure HHV6,7 loads as well as TLRs 2,4 levels . Our results indicated a significant elevation in TLR2,4 in our cases as well as a significant elevation HHV6,7 loads .Furthermore, we detected a significant elevation TLR 2,4 in HHV7 positive cases. Our results concluded that TLR 2,4 are involved in viral diseases particularly HHVs, and supported the possibility that HHV7 and to a lesser extent 6 are involved in the pathogenesis of PR

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.10.Ph.D.2013.Na.E (Browse shelf(Opens below))		Not for loan	01010110063523000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.10.Ph.D.2013.Na.E (Browse shelf(Opens below))	63523.CD	Not for loan	01020110063523000

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Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Verneroloy

Pityriasis rosea (PR) is a common papulosquamous skin disease in which infective agent may be implicated. Reactivation of human herpes virus 7 (HHV-7) and, in some cases human herpes virus 6 (HHV-6) was suggested to occur in PR. The aim of this study is to detect the possibility of HHV 6,7 involvement in the pathogenesis of PR and it's relation with TLRs 2,4. In our study 25 PR patients, and 25 healthy controls were recruited, a skin biopsy from PR lesions was obtained and real-time PCR was performed to measure HHV6,7 loads as well as TLRs 2,4 levels . Our results indicated a significant elevation in TLR2,4 in our cases as well as a significant elevation HHV6,7 loads .Furthermore, we detected a significant elevation TLR 2,4 in HHV7 positive cases. Our results concluded that TLR 2,4 are involved in viral diseases particularly HHVs, and supported the possibility that HHV7 and to a lesser extent 6 are involved in the pathogenesis of PR

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