Transforming growth factor beta 1 gene polymorphism and gene expression of forkhead box p3 in the blood of different cutaneous stages of mycosis f ungoides / Doaa Mohamed Hany Abdellatif Hafez ; Supervised Amira Amin Zayed , Mona R. E. Abdelhalim , Khadiga Sayed Sayed

By:

Doaa Mohamed Hany Abdellatif Hafez

Contributor(s):

Material type: Text

TextLanguage: English Publication details: Cairo : Doaa Mohamed Hany Abdellatif Hafez , 2014Description: 126 Leaves : charts , facsimiles ; 25cmOther title:

تعدد الأشكال النووية المنفردة فى معامل النمو المتحور بيتا 1و التعبير الجيني لفوكس ب 3 فى الدم للمراحل الجلدية المختلفة لمرضى الفطر الفطرانى [Added title page title]

Subject(s):

Online resources:

Click here to access online

Available additional physical forms:

Issued also as CD

Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology Summary: Background:. Mycosis fungoides (MF) is the most common type of cutaneous T {u2013}cell lymphomas (CTCLs). Forkhead box P3 (FOXP3) is the specific marker of regulatory T cells (Tregs) and transforming growth factor beta 1 (TGF-Ý1) is their sword cytokine. Studies about involvement of Tregs in MF are controversial. Dysregulation in TGF- Ý1 signaling pathways has been linked to various cancers. Aim of study: To add more insight to the role played by Tregs in MF, by studying the gene expression of FOXP3 and TGF-Ý1 in the blood of MF patients. It also aimed to analyze the relationship between TGF-Ý1gene polymorphism and susceptibility of MF in a sample of Egyptian MF patients. Patients and methods: This case control study included 55 MF patients and 100 controls examined for TGF-Ý1 gene polymorphism by PCR-RFLP. Gene expression of FOXP3 and TGF- Ý1 in the blood of 25 patients and 25 controls was assessed by real time PCR

Tags from this library: No tags from this library for this title. Log in to add tags.

Average rating: 0.0 (0 votes)

Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.10.Ph.D.2014.Do.T (Browse shelf(Opens below))		Not for loan	01010110063527000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.10.Ph.D.2014.Do.T (Browse shelf(Opens below))	63527.CD	Not for loan	01020110063527000

Browsing المكتبة المركزبة الجديدة - جامعة القاهرة shelves Close shelf browser (Hides shelf browser)

Previous	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	Next
Previous	Cai01.11.10.Ph.D.2013.Ra.O Oral corticosteroids versus narrow-band UVB in the treatment of vitiligo : A comparative study /	Cai01.11.10.Ph.D.2013.Se.S Sweat glands in cutaneous drug reactions : A Histopathological, Histochemical and Immunohistochemical Study /	Cai01.11.10.Ph.D.2013.Se.S Sweat glands in cutaneous drug reactions : A Histopathological, Histochemical and Immunohistochemical Study /	Cai01.11.10.Ph.D.2014.Do.T Transforming growth factor beta 1 gene polymorphism and gene expression of forkhead box p3 in the blood of different cutaneous stages of mycosis f ungoides /	Cai01.11.10.Ph.D.2014.Do.T Transforming growth factor beta 1 gene polymorphism and gene expression of forkhead box p3 in the blood of different cutaneous stages of mycosis f ungoides /	Cai01.11.10.Ph.D.2014.Ha.M Molecular study of endothelin-1 and endothelin beta receptor genes in vitiligo patients /	Cai01.11.10.Ph.D.2014.Ha.M Molecular study of endothelin-1 and endothelin beta receptor genes in vitiligo patients /	Next

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Background:. Mycosis fungoides (MF) is the most common type of cutaneous T {u2013}cell lymphomas (CTCLs). Forkhead box P3 (FOXP3) is the specific marker of regulatory T cells (Tregs) and transforming growth factor beta 1 (TGF-Ý1) is their sword cytokine. Studies about involvement of Tregs in MF are controversial. Dysregulation in TGF- Ý1 signaling pathways has been linked to various cancers. Aim of study: To add more insight to the role played by Tregs in MF, by studying the gene expression of FOXP3 and TGF-Ý1 in the blood of MF patients. It also aimed to analyze the relationship between TGF-Ý1gene polymorphism and susceptibility of MF in a sample of Egyptian MF patients. Patients and methods: This case control study included 55 MF patients and 100 controls examined for TGF-Ý1 gene polymorphism by PCR-RFLP. Gene expression of FOXP3 and TGF- Ý1 in the blood of 25 patients and 25 controls was assessed by real time PCR

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer