Leukemic stem cell enumeration in acute myeloid leukemia : Relation to prognosis / Lamiaa Mohammad kamal ; Supervised Iman Maher Mansour , Nahed Abdelwahab Mohammad , Lobna Ossama Elmeseery

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Lamiaa Mohammad kamal

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TextLanguage: English Publication details: Cairo : Lamiaa Mohammad kamal , 2014Description: 137 P. : charts ; 25cmOther title:

تعداد الخلايا الجذعية اللوكيميه في اللوكيميا النقيانيه الحاده وبيان العلاقه بعاقبة المرض [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: The poor response to therapy in acute myeloid leukemia (AML) raises the expectations that the presence of leukemic stem cells (LSCs) may add to therapy resistance. Using flowcytometry, we analyzed the expression of CD123 among CD34+CD38- cells in AML patients at initial diagnosis and on day 14 post induction. We concluded thatCD123 may be used as marker of LSCs in AML, presence of LSCs at diagnosis had no prognostic impact on treatment outcome and the emergence of LSCs in post induction samples may reflect an induced stem cell theory contributing further to disease resistance

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.La.L (Browse shelf(Opens below))		Not for loan	01010110063874000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.La.L (Browse shelf(Opens below))	63874.CD	Not for loan	01020110063874000

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Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

The poor response to therapy in acute myeloid leukemia (AML) raises the expectations that the presence of leukemic stem cells (LSCs) may add to therapy resistance. Using flowcytometry, we analyzed the expression of CD123 among CD34+CD38- cells in AML patients at initial diagnosis and on day 14 post induction. We concluded thatCD123 may be used as marker of LSCs in AML, presence of LSCs at diagnosis had no prognostic impact on treatment outcome and the emergence of LSCs in post induction samples may reflect an induced stem cell theory contributing further to disease resistance

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