Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Forensic Medicine and Toxicology

Aluminum is a silver-white, malleable, and ductile metal and the third most abundant element in the earth{u2019}s crust, comprising 8.3 percent of its volume. This study concerns with Al hepatoxicity either in vitro or in vivo and the role of DFO and L1as chelating agents to alleviate this effect. Isolated rat hepatocytes were exposed to different concentrations of AlCl (5, 10, 20 æM) to examine AlCl-induced hepatotoxicity. The isolated hepatocytes at the submaximal dose of ALCl were pre-treated with either DFO or L1 to determine their protective effects. Present results indicated that the viability and enzymatic leakage % of LDH, ALT, and AST were significantly affected by AlCl toxicity. Oxidative stress assessed by GSH & TBA-RS levels was also observed. Addition of DFO & L1 to incubated hepatocytes 60 minutes before AlCl exposure resulted in marked ameliorating effect

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