Polymorphisms in foxo 1a & 3a gene family and its relation to obesity / Shereen Hamdy Abdelaziz Elsayed ; Supervised Safaa Mostafa Elkaraksy , Shadia Hassan Ragab , Noha Mohamed Hosni Shaheen

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Shereen Hamdy Abdelaziz Elsayed

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TextLanguage: English Publication details: cairo : Shereen Hamdy Abdelaziz Elsayed , 2014Description: 125 P. : charts , facsimiles ; 25cmOther title:

١وعلاقته بالسمنةa &٣a تعدد آليات عائلة جين الفوكسو [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Obesity is a multifactorial disease with genetic and environmental origins, resulting from imbalance between energy intake and expenditure. Our study aimed at studying the association between FoxO genes (1a& 3 a) polymorphisms and obesity, we found that polymorphism existed only in obese patients although the controls showed no polymorphisms in either FoxO genes (1a & 3a). Also, we found a statistically significant positive correlation between increase fasting insulin, insulin resistance and FoxO 1a polymorphism. Increase fasting insulin and increase insulin resistance will lead to obesity. So, this correlation indicates that if the individual has FoxO 1a gene polymorphism, he will have strong chance to be obese. This patient must follow all the strategies for obesity prevention and management including physical activity, diet control and behavioral changes

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.Sh.P (Browse shelf(Opens below))		Not for loan	01010110064669000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.Sh.P (Browse shelf(Opens below))	64669.CD	Not for loan	01020110064669000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Obesity is a multifactorial disease with genetic and environmental origins, resulting from imbalance between energy intake and expenditure. Our study aimed at studying the association between FoxO genes (1a& 3 a) polymorphisms and obesity, we found that polymorphism existed only in obese patients although the controls showed no polymorphisms in either FoxO genes (1a & 3a). Also, we found a statistically significant positive correlation between increase fasting insulin, insulin resistance and FoxO 1a polymorphism. Increase fasting insulin and increase insulin resistance will lead to obesity. So, this correlation indicates that if the individual has FoxO 1a gene polymorphism, he will have strong chance to be obese. This patient must follow all the strategies for obesity prevention and management including physical activity, diet control and behavioral changes

Issued also as CD

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