Prognostic impact of epidermal growth factor receptor (EGFR) mutations in lung cancer / Fatma Hassan Abdelraouf ; Supervised Taghrid Mohamed Gaafar , Mary O{u2019}brien , Ayatallah Amir Nassef

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Fatma Hassan Abdelraouf

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TextLanguage: English Publication details: Cairo : Fatma Hassan Abdelraouf , 2014Description: 196 P. : charts , facsimiles ; 25cmOther title:

تأثيرطفرات مستقبل عامل نمو البشرة على مدى تطور مرض سرطان الرئة [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Molecular biomarkers have been investigated in non-small cell lung cancer (NSCLC) and targeted treatments in advanced disease are established. However, there are no established targeted therapies at the moment for small cell lung cancer (SCLC). The aim of this study was to examine for the presence of known molecular targets in patients with SCLC and their prognostic effect. A panel of histopathologically proven FFPE specimens of SCLC were analysed for EGFR, KRAS, NRAS, BRAFmutations, ALK gene rearrangements and MET amplification. EGFR and KRAS testing were done using real time - polymerase chain reaction (RT - PCR cobas®), BRAF and NRAS using multiplex PCR and capillary electrophoresis-single strand conformation analysis (CE - SSCA) and ALK and MET using fluorescent in situ hybridization (FISH). Any positive results were repeated for confirmation. Any inconsistent results were sequenced using the direct sanger sequencing

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.Fa.P (Browse shelf(Opens below))		Not for loan	01010110064882000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.Fa.P (Browse shelf(Opens below))	64882.CD	Not for loan	01020110064882000

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Previous	Cai01.11.07.Ph.D.2014.Ez.H Haemochromatosis gene mutations in chronic hepatitis {u2018}C{u2019} patiens /	Cai01.11.07.Ph.D.2014.Ez.H Haemochromatosis gene mutations in chronic hepatitis {u2018}C{u2019} patiens /	Cai01.11.07.Ph.D.2014.Fa.P Prognostic impact of epidermal growth factor receptor (EGFR) mutations in lung cancer /	Cai01.11.07.Ph.D.2014.Fa.P Prognostic impact of epidermal growth factor receptor (EGFR) mutations in lung cancer /	Cai01.11.07.Ph.D.2014.He.A Association of platelet endothelial cell adhesion molecule - 1 (PECAM -1) gene polymorphisms with coronary artery disease /	Cai01.11.07.Ph.D.2014.He.A Association of platelet endothelial cell adhesion molecule - 1 (PECAM -1) gene polymorphisms with coronary artery disease /	Cai01.11.07.Ph.D.2014.He.P The prognostic value of adenosine triphosphate (ATP) binding Cassette (ABCB5) and Multidrug resistance (MDR1) genes` expression in acute leukemias /	Next

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Molecular biomarkers have been investigated in non-small cell lung cancer (NSCLC) and targeted treatments in advanced disease are established. However, there are no established targeted therapies at the moment for small cell lung cancer (SCLC). The aim of this study was to examine for the presence of known molecular targets in patients with SCLC and their prognostic effect. A panel of histopathologically proven FFPE specimens of SCLC were analysed for EGFR, KRAS, NRAS, BRAFmutations, ALK gene rearrangements and MET amplification. EGFR and KRAS testing were done using real time - polymerase chain reaction (RT - PCR cobas®), BRAF and NRAS using multiplex PCR and capillary electrophoresis-single strand conformation analysis (CE - SSCA) and ALK and MET using fluorescent in situ hybridization (FISH). Any positive results were repeated for confirmation. Any inconsistent results were sequenced using the direct sanger sequencing

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