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A comparative study on treatment of vitiligo using systemic steroids versus combined NB - UVB with systemic steroids / Iman Sany Zaky Hassan ; Supervised Medhat Abdelmoneim Elmofty , Doaa M. Aly Mahgoub , Amira Mohamed Eltawdy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Iman Sany Zaky Hassan , 2014Description: 143 P. ; 25cmOther title:
  • دراسة فى علاج البهاق باستخدام الكورتيزون عن طريق الفم مقارنة باستخدامه مع الأشعة فوق البنفسجية ب ضيقة المدى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology Summary: The pathogenesis of vitiligo is complex and not yet fully understood, but it is believed to involve a combination of autoimmune, genetic, and environmental factors. Classic treatment options for vitiligo include narrow band UVB and psoralens plus UVA (PUVA). Oral steroids have been tried and reported to be effective in the treatment of vitiligo. To assess clinical efficacy of NB - UVB combined with oral steroids compared to oral steroids alone in treatment of stable vitiligo patients, as well as observe any relapse/rebound that may possibly occur following cessation of treatment. 30 patients with stable vitiligo randomized into 2 groups; group A received NB - UVB for 36 sessions with oral steroids, whilst group B received oral steroids alone for 3 months. Both groups were followed up for 3 months. Basic fibroblast growth factor (bFGF) (marker of regression) and intercellular adhesion molecule (ICAM 1) (marker of activity) tissue levels were measured by RT - PCR before and after treatment and after follow-up. Anti-melanocyte antibodies (AMA) (marker of activity) detection in patients' sera was done using cellular eliza before and after treatment and after follow up
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.Ph.D.2014.Im.C (Browse shelf(Opens below)) Not for loan 01010110065683000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.Ph.D.2014.Im.C (Browse shelf(Opens below)) 65683.CD Not for loan 01020110065683000

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Cai01.11.10.Ph.D.2014.Do.T Transforming growth factor beta 1 gene polymorphism and gene expression of forkhead box p3 in the blood of different cutaneous stages of mycosis f ungoides / Cai01.11.10.Ph.D.2014.Ha.M Molecular study of endothelin-1 and endothelin beta receptor genes in vitiligo patients / Cai01.11.10.Ph.D.2014.Ha.M Molecular study of endothelin-1 and endothelin beta receptor genes in vitiligo patients / Cai01.11.10.Ph.D.2014.Im.C A comparative study on treatment of vitiligo using systemic steroids versus combined NB - UVB with systemic steroids / Cai01.11.10.Ph.D.2014.Im.C A comparative study on treatment of vitiligo using systemic steroids versus combined NB - UVB with systemic steroids / Cai01.11.10.Ph.D.2014.Pa.C Comparative study using Adipose derived stem cells enriched fat graft versus Platelet rich plasma enriched fat graft versus Enriched fat graft with both Platelet rich plasma and adipose derived stem cells for treatment of acne scars / Cai01.11.10.Ph.D.2014.Pa.C Comparative study using Adipose derived stem cells enriched fat graft versus Platelet rich plasma enriched fat graft versus Enriched fat graft with both Platelet rich plasma and adipose derived stem cells for treatment of acne scars /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

The pathogenesis of vitiligo is complex and not yet fully understood, but it is believed to involve a combination of autoimmune, genetic, and environmental factors. Classic treatment options for vitiligo include narrow band UVB and psoralens plus UVA (PUVA). Oral steroids have been tried and reported to be effective in the treatment of vitiligo. To assess clinical efficacy of NB - UVB combined with oral steroids compared to oral steroids alone in treatment of stable vitiligo patients, as well as observe any relapse/rebound that may possibly occur following cessation of treatment. 30 patients with stable vitiligo randomized into 2 groups; group A received NB - UVB for 36 sessions with oral steroids, whilst group B received oral steroids alone for 3 months. Both groups were followed up for 3 months. Basic fibroblast growth factor (bFGF) (marker of regression) and intercellular adhesion molecule (ICAM 1) (marker of activity) tissue levels were measured by RT - PCR before and after treatment and after follow-up. Anti-melanocyte antibodies (AMA) (marker of activity) detection in patients' sera was done using cellular eliza before and after treatment and after follow up

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