Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Background: Overactive bladder (OAB) is a common clinical problem. Materials and methods: Experimental study: seventy two adult male albino rats weighing 250-300 g, were classified into six groups. Blood glucose, cystometry, dose concentration response to Ach and histopathological examination were done.Clinical Study: The study was conducted on fifty with type-1 diabetes mellitus and over active bladder divided into five groups. Urodynamic studies were done and voiding diary and lower urinary symptom sheet was collected from each patient before and after treatment. Results: Experimental findings: Diabetic rats exhibited a significant increase in the intravesical pressures, in tonic contractions to submaximal dose of ACh. and in bladder weight/body weight ratio and musculosa thickness compared to control group, while a significant reduction in those parameters were found in diabetic treated groups to diabetic group. For bladder volume, Oxybutinin and Tolterodine showed significant decrease while Nicorandil and Carbamazepine groups showed significant increase. Clinical findings: in Oxybutinin, Tolterodine groups urodynamic parameters and bladder capacities were significantly changed compared to placebo group while insignificant change were found in Nicorandil and Carbamazepine groups. Conclusion:Carbamazepine and Nicorandil potentially suppress the overactive bladder resulted from diabetes as shown in experimental work. On the other hand the clinical study didn't show a significant role for both drugs which needs further clinical trials with a more objective investigation

Issued also as CD