Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Objective: to detect the prevalence, risk factors, response to various modalities of treatment and outcome among cases of kernicterus admitted in Cairo University Children hospital NICU. Methods: a one year prospective analysis of all cases of acute bilirubin encephalopathy admitted to NICU of CUPH during the period from the first of September 2014 to the end of August 2015. Results: eighty one newborns, having severe hyperbilirubinemia with signs or symptoms suggestive of acute bilirubin encephalopathy, were recorded. They represented 12% of the total number of the neonates admitted to the NICU with jaundice. The mean gestational age was 38.1 ± 1.1 weeks; the mean age of onset of jaundice was 2.8 ± 1.7 days. Admission TSB value was ranged from17.5 to 75.2mg/dl. The presence of hemolysis was detected in 40.7%.ABO incompatibility was found in 50.6% of cases, Rh incompatibility in 27.2% and neonatal sepsis in 21%.Their outcome showed a mortality in 9.9% of cases, the living cases with parietal recovery accounted for 58%. Admission BIND score showed significant positive correlation with: TSB at admission and significant negative correlation with hemoglobin and hematocrit. BIND score at discharge showed significant positive correlation with TSB at onset, TSB at admission, TSB after treatment, BIND score at admission, BIND score after treatment and significant negative correlation with hemoglobin and hematocrit. The linear (standard) regression model showed that only TSB at admission and maternal illiteracy were the significant predictors of BIND score at admission. Similarly, only BIND score at admission could significantly determine the variation in BIND score at discharge

Issued also as CD