Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurology

Growing evidence indicates that oxidative stress plays a major role in the pathogenesis of MS. While lipid oxidation in neurodegenerative disorders and in MS has been extensively studied, protein oxidation has received little attention. Previous experimental studies have shown that protein oxidation may also play a critical physiopathological role in inflammatory demyelinating diseases. Protein carbonyls are found to be augmented in MS and have been implicated in the pathophysiology of MS. To study the levels of carbonyl protein and ferritin in patients with multiple sclerosis in both relapsing remitting and progressive forms of the disease and to study the relation between oxidative stress biomarkers and the clinical parameters and functional disability of MS patients and the radiological features in MS. This study was conducted on 50 Egyptian MS patients and 30 healthy control subjects divided ito three groups; Group 1: 30 Patients diagnosed with RRMS, group 2: 20 patients diagnosed with SPMS and group 3: 30 healthy control subjects. Patients were subjected to clinical evaluation (history and examination); MS patients were assessed by expanded disability status scale (EDSS). MRI brain was done to all MS patients. Blood samples were collected for measurement of serum level of carbonyl protein and ferritin

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