On the page title faculty of medicine

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology

Osteosarcoma is a primary malignant tumor of bone, derived from primitive bone forming mesenchyme and characterized by the production of osteoid tissue or immature bone by the malignant proliferating spindle cell stroma. This prospective study was designed to determine whether postoperative dose intensification with etoposide and ifosfamide can improve outcome for standard responders to preoperative chemotherapy. This retrospective study was carried out in the pediatric oncology department of the National cancer institute (NCI), Cairo university and Naser institute during the period from April 2010 to March 2012. Ninety two patients presented with histopathological diagnosis of osteosarcoma were eligible for entry in the treatment protocol. The age of the 92 patients included in the study ranged from 5 years to 35 years with a mean age of 15.6 years and a median age of 15 years. In our study sex, extent of the intial disease pathological type, tumor necrosis and tumor size were statistically significant both DFSand OS. The 3 years DFS in male group was 48.9% while in female group was 78.6%. The difference between 2 groups was statistically significant (P=0.007). The tumor size was calculated and categorized into two groups, one group with tumor{u2264}10cm, the other group with tumor >10cm. fifty patients (50/87, 57.4%) fit into the less than or equal 10cm category and thirty seven patients (37/87, 42.5%) fit into greater than 10 cm category, with DFS at 3 years of 86%and 32% respectively

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