Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Cystic fibrosis is the most common life-limiting autosomal recessive disease among people in the USA and europe with increased prevalence in Egypt. Pulmonary disease is the most important cause of morbidity and mortality in CF. Affected children are also in danger of acute kidney injury and the development of chronic renal disease due to presence of CFTR gene in renal tubules as well as exposure to multiple potentially nephrotoxic agents including aminoglycosides, non-steroidal anti-inflammatory drugs NSAIDs and immune-suppressants. The aim of our study is to early detection of renal impairment in Egyptian patients with CF and hence careful monitoring and adjustment of medications especially nephrotoxic drugs like garamycin, Amikacin and Ciprofloxacin which are used repeatedly in these patients. Fifty CF patients were enrolled in our study from the allergy and pulmonology unit in children hospital of Cairo university. Diagnosed based on clinical manifestations and elevated sweat chloride testing{u2265}60mg/L. They were age and sex matched to forty healthy children as a control group. All patients are screened for renal affection by measuring urine analysis, kidney function tests, FENa, Ý2MG, KIM-1 in urine using ELISA technique and renal U/S. Out of 50 children there are 30 patients (60%) have high levels of Ý2MG and 33 patients (66%) have high levels of KIM-1. There were significant differences between Ý2MG enzyme level and KIM-1 enzyme level in case and control children (P value<0.05). Serum creatinine and renal U/S were normal for all patients. There was significant Correlation between urinary Ý2MG, KIM-1 enzymes elevation and duration of disease P value<0.01, P value<0.01 respectively

Issued also as CD