Design, preparation and evaluation of a certain phosphodiesterase (PDE5) inhibitor in solid dosage forms / Karim Aboubakr Mohamed Mohamed Soliman ; Supervised Mahmoud Mohammed Ghorab , Howida Kamal Ibrahim
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TextLanguage: English Publication details: Cairo : Karim Aboubakr Mohamed Mohamed Soliman , 2016Description: 288 P. : charts , facsimiles ; 30cmOther title: - تصميم وتحضير وتقييم لعقار مثبط لانزيم الفوسفوديستريس في صورة مستحضرات صيدلية صلبة [Added title page title]
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Thesis
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.08.08.Ph.D.2016.Ka.D (Browse shelf(Opens below)) | Not for loan | 01010110072001000 | ||
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.08.08.Ph.D.2016.Ka.D (Browse shelf(Opens below)) | 72001.CD | Not for loan | 01020110072001000 |
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| Cai01.08.08.Ph.D.2016.Ho.S Study of the niosomal encapsulation of an anticancer drug and its effect on efficacy and safety / | Cai01.08.08.Ph.D.2016.Ho.S Study of the niosomal encapsulation of an anticancer drug and its effect on efficacy and safety / | Cai01.08.08.Ph.D.2016.Ka.D Design, preparation and evaluation of a certain phosphodiesterase (PDE5) inhibitor in solid dosage forms / | Cai01.08.08.Ph.D.2016.Ka.D Design, preparation and evaluation of a certain phosphodiesterase (PDE5) inhibitor in solid dosage forms / | Cai01.08.08.Ph.D.2016.La.P Preparation and evaluation of pH sensitive microparticles for colonic targeting / | Cai01.08.08.Ph.D.2016.La.P Preparation and evaluation of pH sensitive microparticles for colonic targeting / | Cai01.08.08.Ph.D.2016.Ma.A Application of nanotechnology for ocular drug delivery / |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
vanafil is an inhibitor of phosphodiesterase enzyme type 5 (PDE5). It was approved for treatment of erectile dysfunction by US Food and Drug Administration on April 2012, and by European Medicines Agency on June 2013. It is characterized by its rapid onset of action and it exhibits visual side effects to a lesser extent than other PDE5 inhibitors. It is poorly soluble in water and has relatively low bioavailability of 38%{u2013}41%. Its oral bioavailability could be increased by improving its aqueous solubility using different techniques. These include nanocrystallization, inclusion complexation and nanoemulsification
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