Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Thirty patients, who received living donor kidney transplant and being followed up at the kidney Transplantation Outpatient Clinic, Cairo University Monira Children Hospital, were included. Initial assessment, as well as, 3 & 6 months follow up assessment of height (SD), body weight (SD), and body mass index (BMI) were done. Initial and 6 months follow up bone age estimation was also done. Data obtained by combined history and medical record review. Obtained data and assessment parameters were interpreted. Results: At initial assessment; 21 patients (70%) were stunted (height < -2 SD), 9 patients (30%) were under weight (weight<-2SD), 7 patients (23.3%) were obese (BMI > +2 SD), the prevalence of delayed growth did not change much at 6 months F/U assessment. The mean growth velocity SDS of the study group was 2.1at 3months and 2.8 at 6months following the initial assessment with the mean delta SDS of growth velocity (0.67).Significant correlations existed between height SDS and steroid doses at 6 months post-transplantation as well as frequency of BPAR (p=0.033, 0.011 respectively). Body weight SDS at 6months F/U assessment significantly correlated with age at diagnosis of CRI (p=0.029), and duration of dialysis (p=0.029) Conclusion: The mean growth velocity increase in renal transplanted children, with follow up assessment over 6 months, but still suboptimal. Post transplantation growth is affected with type of inherited renal disease, age of diagnosis, time of referral, early dialysis, steroid exposure, and acute rejection episodes

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