Preparation of inactivated trivalent vaccine of New castle disease virus and avian influenza viruses subtypes H5N1 and H9N2 / Zeinab Mohamed Ali ; Supervised Ahmed Abdelghani Elsanousi , Hussein Ali Hussein , Mervat Abdelmonaem Elkoufy

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Zeinab Mohamed Ali

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TextLanguage: English Publication details: Cairo : Zeinab Mohamed Ali , 2017Description: 121 P. : charts ; 25cmOther title:

H9N2 و H5N1 تحضير لقاح ثلاثى مثبط من فيروسات مرض النيوكاسل و انفلونزا الطيور نوعى [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Virology Summary: The present study was to prepare a trivalent inactivated vaccine ND, H5N1 and H9N2 viruses. Three monovalent and one trivalent vaccines were prepared by emulsifying inactivated NDV (LaSota strain),reassortant H5N1 and H9N2 viruses with Montanide ISA 71 oil adjuvant. Parameters used for evaluation of efficacy of the prepared vaccines in SPF chickens were cellular immunity assays (blastogenesis, IF gamma, IL1 and IL6) .and humoral immunity by HI, protection % and shedding were also determined. A single immunization with tivalent vaccine enhances cell mediated immunity as well as humoral immune response with 90% protection against challenges with HPAI H5N1 and LPAI H9N2 viruses with 100% protection were obtained after challenge with NDV comparing the trivalent vaccine with monovalent vaccines in the study report the success in preparation of a potent and efficient trivalent vaccine which is a promising approach for controlling HPAI H5N1, low pathogenic H9N2 and ND viral infections

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.10.17.Ph.D.2017.Ze.P (Browse shelf(Opens below))		Not for loan	01010110075240000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.10.17.Ph.D.2017.Ze.P (Browse shelf(Opens below))	75240.CD	Not for loan	01020110075240000

Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Virology

The present study was to prepare a trivalent inactivated vaccine ND, H5N1 and H9N2 viruses. Three monovalent and one trivalent vaccines were prepared by emulsifying inactivated NDV (LaSota strain),reassortant H5N1 and H9N2 viruses with Montanide ISA 71 oil adjuvant. Parameters used for evaluation of efficacy of the prepared vaccines in SPF chickens were cellular immunity assays (blastogenesis, IF gamma, IL1 and IL6) .and humoral immunity by HI, protection % and shedding were also determined. A single immunization with tivalent vaccine enhances cell mediated immunity as well as humoral immune response with 90% protection against challenges with HPAI H5N1 and LPAI H9N2 viruses with 100% protection were obtained after challenge with NDV comparing the trivalent vaccine with monovalent vaccines in the study report the success in preparation of a potent and efficient trivalent vaccine which is a promising approach for controlling HPAI H5N1, low pathogenic H9N2 and ND viral infections

Issued also as CD

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