Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Nuclear Medicine

Background: The aim of this study was to investigate whether diffuse hepatic and thyroid bed uptake of 131I on post-ablative whole body iodine scans (PAWBIS) of patients with differentiated thyroid cancer (DTC) have any relevance for clinical outcome and parameters. Patients and Methods: We prospectively investigated 195 patients with DTC, who were treated at Kasr-Alainy Hospital, Cairo University from 2015 to 2017. Grades of hepatic and thyroid bed uptake on 131I whole body scan were classified from 0 to 3 by visual assessment. Recurrence-free survival was evaluated with the Kaplan-Meier method and Cox regression analysis. Results: Male patients (p< 0.004) above 45 years (p < 0.005) having tumors larger than 1 cm (p = 0.005), multiple tumor foci (p < 0.02), and a higher TNM stage (p < 0.003) with positive history of metastatic cervical LNs (p < 0.05) were associated with bad outcomes. Female patients, unifocal tumors and high grades of liver uptake were identified as independent good prognostic factors with (p values 0.048, 0.042, 0.009) respectively. Intense thyroid bed uptake and faint hepatic activity were related to poor prognosis

Issued also as CD