Galectin - 1 stimulated signaling events in T - lymphocytes / Ehab Fathi Gabr Aboueladab ; Supervised Abd El gawad Fahmi , Mohamed Ali Eldesokey , Joesef Brock

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Ehab Fathi Gabr Aboueladab

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Language: Eng Publication details: Cairo : Ehab Fathi Gabr Aboueladab , 2006Description: 116L : ill ; 30cmOther title:

جاليكتين - 1 كمنبه للاشارات المرسلة لخلايا تى الليمفاوية [Added title page title]

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Dissertation note: Thesis (PH.D.) - Cairo University - Faculty Of Science - Department Of Biochemistry Summary: This work has been carried out to investigate the mechanisms of T cell activation on the level of signal transduction induced by galectin - 1 (gal - 1) having immunosuppressive activityGal - 1 recognizes and cross - links appropriate glycoepitopes (Gal?1 - 4GlcNAc - sequences) on T cell activation markers (CD2 , CD3 , CD45) and stimulates in parallel several interacting signalling pathways leading to suppression of the expression of Th1 cytokines and to apoptosis in thymocytes , activated T - cells , and in leukemic T cell linesIn cellular models by applying cell - and glycobiological methods we have focused on gal - 1 induced or suppressed signalling pathways involved in inhibition of a processive immune response of antigen - stimulated T lymphocytesIn this way , by depletion of activated T cells gal - 1 is a negative regulator of the immune responseTherefore , the mechanism of gal - 1 induced T cell apoptosis is of special interest

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Item type	Current library	Home library	Call number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.02.Ph.D.2006.Eh.G. (Browse shelf(Opens below))	Not for loan	01010110046018000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.02.Ph.D.2006.Eh.G. (Browse shelf(Opens below))	Not for loan	01020110046018000

Thesis (PH.D.) - Cairo University - Faculty Of Science - Department Of Biochemistry

This work has been carried out to investigate the mechanisms of T cell activation on the level of signal transduction induced by galectin - 1 (gal - 1) having immunosuppressive activityGal - 1 recognizes and cross - links appropriate glycoepitopes (Gal?1 - 4GlcNAc - sequences) on T cell activation markers (CD2 , CD3 , CD45) and stimulates in parallel several interacting signalling pathways leading to suppression of the expression of Th1 cytokines and to apoptosis in thymocytes , activated T - cells , and in leukemic T cell linesIn cellular models by applying cell - and glycobiological methods we have focused on gal - 1 induced or suppressed signalling pathways involved in inhibition of a processive immune response of antigen - stimulated T lymphocytesIn this way , by depletion of activated T cells gal - 1 is a negative regulator of the immune responseTherefore , the mechanism of gal - 1 induced T cell apoptosis is of special interest

Issued also as CD

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