Synthesis of some new pyrazole and pyrazolopyrimidine derivatives of expected analgesic and antiinflammatory activity / Reham Sayed Ibrahim ; Supervised Afaf Kamal Eldin Elansary , Ehab Mohamed Gedawy , Elham Azz Elarab
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TextLanguage: English Publication details: Cairo : Reham Sayed Ibrahim , 2018Description: 138 P. : charts , facsimiles ; 25cmOther title: - تشييد بعض مركبات البيرازول ومشتقات البيرازولوبيرمدين الجديده ذات تاثير مسكن متوقع و مضاد للالتهاب [Added title page title]
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Thesis
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.08.04.M.Sc.2018.Re.S (Browse shelf(Opens below)) | Not for loan | 01010110077968000 | ||
CD - Rom
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.08.04.M.Sc.2018.Re.S (Browse shelf(Opens below)) | 77968.CD | Not for loan | 01020110077968000 |
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| Cai01.08.04.M.Sc.2018.Mo.S Synthesis of New fused pyrimidine derivatives with expected pharmaceutical interest / | Cai01.08.04.M.Sc.2018.Ne.S Synthesis of novel oxadiazole and chromene derivatives as cytotoxic agents / | Cai01.08.04.M.Sc.2018.Ne.S Synthesis of novel oxadiazole and chromene derivatives as cytotoxic agents / | Cai01.08.04.M.Sc.2018.Re.S Synthesis of some new pyrazole and pyrazolopyrimidine derivatives of expected analgesic and antiinflammatory activity / | Cai01.08.04.M.Sc.2018.Re.S Synthesis of some new pyrazole and pyrazolopyrimidine derivatives of expected analgesic and antiinflammatory activity / | Cai01.08.04.M.Sc.2018.Sh.S Synthesis of new pyrazoles as anti-inflammatory agents / | Cai01.08.04.M.Sc.2018.Sh.S Synthesis of new pyrazoles as anti-inflammatory agents / |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry
Novel pyrazole and pyrazolo[3,4-d]pyrimidine derivatives were prepared and evaluated for their analgesic activity. The most potent compounds V,Vb, IX, XIId, XIIIc,d, XIVa, XV were further evaluated for their antiinflammatoryactivity. Compounds VIb, IX, XIIIc,d were further evaluated for their ulcerogenic activity. Compounds VIb, IX, XIIId undergo in-vitro COX-II inhibitory activity assay. All Final prepared compounds were studied by molecular docking studies. Compound VIb showed both high analgesic, antiinflammatory, no ulcerogenic effect in addition to its higher selectivity index for COX-II enzyme with SI = 5.1 when comparing to celecoxib with SI = 6.2 exhibiting moderate binding energy -24.12 score Kcal/mol
Issued also as CD
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