Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

edefine sepsis as agreed upon by The Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM) as the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) (Singer M., et al. 2016). Sepsis: 2life-threatening organ dysfunction caused by a dysregulated host response to infection.3 End organ damage is identified as an acute change in total Sequential [Sepsis-related] Organ Failure Assessment score (SOFA) {u2265}2 (Rhodes A., et al 2016). Septic shock: A subset of sepsis 2in which circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. These patients can be clinically identified by a vasopressor requirement to maintain a MAP {u2265} 65mmHg and serum lactate >2mmol/L in the absence of hypovolemia (Singer M., et al 2016)

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