Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Internal Medicine and Infectious Diseases

Gastrointestinal disorders are one of the most common affections encountered in veterinary canine practice and reasons for seeking veterinary assistance in small animal practice. They have multiple etiologies to occur for example food indiscretions, allergies, drug interactions, viral, bacterial, and parasitic infection. The most signified signs are vomiting and diarrhea. This current study targeted to estimate alteration on hematology and oxidative stress biomarkers in selected gastrointestinal diseases. This study enrolled 64 dogs, divided into 22 apparently healthy dog served as control and 42 diseased dogs (14 suffered from canine parvovirus enteritis; 10 dogs with gastroenteritis caused by parasitic infection; 10 Suffered from gastritis and 8 Suffered from enteritis). Blood samples were collected from each animal for clinical hematology, oxidant biomarkers MDA, H2O2 and antioxidant biomarkers SOD, GPX, Catalase, TAC, Zn, Cu, iron. Cortisol level, Cl and k were also estimated in serum. Dogs with parvovirus infection showed increase in MDA, H2O2, SOD, GPX, and decrease of catalase, Zn, Cu and Fe. Increased SOD, MDA, and cortisol, with decrease in GPx, catalase, Cu, Zn and Fe were recorded in both gastritis group and enteritis group. However, H2O2 level decreased in gastritis and increased in enteritis group. In dogs with gastroenteritis caused by parasitic infection, drop in hemoglobin, PCV, catalase and GPx along with rise in SOD and cortisol were recorded. In conclusion, alteration in oxidant stress biomarkers is associated with presented gastrointestinal disorders

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