Bone marrow transplantation in bone marrow failure syndromes : The Egyptian outcome / Vivian Farouk Lotfy Ghattas ; Supervised Amal Mohamed Elbeshlawy , Alaa Mohamed Elhaddad , Amina Abdelsalam Mahmoud

By:

Vivian Farouk Lotfy Ghattas

Contributor(s):

Material type: Text

TextLanguage: English Publication details: Cairo : Vivian Farouk Lotfy Ghattas , 2019Description: 171 P. : charts , facsimiles ; 25cmOther title:

زرع الخلا{u٠٦أأ}ا الجذع{u٠٦أأ}ة فى امراض فشل النخاع : النتائج المصر{u٠٦أأ}ة [Added title page title]

Subject(s):

Online resources:

Click here to access online

Available additional physical forms:

Issued also as CD

Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Background&Objectives:Hematopoietic stem cell transplantation (HSCT) offers potentially curative treatmnt for bone marrow failure syndromes (BMFS). We aimed to evaluate the BMFS-free survival and outcome of stem cell transplantation in the Egyptian experience and to analyze the patients and donors{u2019} characteristics as well as transplantation related factors that could affect the graft success rate. Methods: This study retrospectively analyzed 147 patients who underwent stem cell transplantation for BMFS (congenital or acquired) in Nasser institute, between January 2009 and December 2015.Results: Patients{u2019} age at the time of transplantation ranged from 1.0 to 18.0 years; with a mean of10.5±4.9 and median 10 years. Ninety four were males (M/F ratio: 1.7). Out of the 147 patients; 10 (6.8%) patients received bone marrow and 137(93.2%) received peripheral blood stem cells (PBSC) harvest. All donors were HLA identical with 137 matched sibling donors and 10 matched parent donors. Transplant related mortality was 23.8% and the most common cause of death was infection in 57.1% of cases.The probabilities of 5- year overall survival (OS) was 73.4%,disease free survival (DFS) was 74.2 % andevent free survival (EFS) was 70.4%. OS and DFS were significantly worse in patients who had aGVHD (p=0.001, 0.001 respectively)

Tags from this library: No tags from this library for this title. Log in to add tags.

Average rating: 0.0 (0 votes)

Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.28.M.Sc.2019.Vi.B (Browse shelf(Opens below))		Not for loan	01010110080431000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.28.M.Sc.2019.Vi.B (Browse shelf(Opens below))	80431.CD	Not for loan	01020110080431000

Browsing المكتبة المركزبة الجديدة - جامعة القاهرة shelves Close shelf browser (Hides shelf browser)

Previous	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	Next
Previous	Cai01.11.28.M.Sc.2019.Ta.R Relationship between anthropometric measures and pulmonary functions in obese children and adolescents /	Cai01.11.28.M.Sc.2019.Ta.R Relationship between anthropometric measures and pulmonary functions in obese children and adolescents /	Cai01.11.28.M.Sc.2019.Vi.B Bone marrow transplantation in bone marrow failure syndromes : The Egyptian outcome /	Cai01.11.28.M.Sc.2019.Vi.B Bone marrow transplantation in bone marrow failure syndromes : The Egyptian outcome /	Cai01.11.28.M.Sc.2019.Ya.T Transfusional profile in emergency room pediatric intensive Care Unit in Cairo University children hospital /	Cai01.11.28.M.Sc.2019.Ya.T Transfusional profile in emergency room pediatric intensive Care Unit in Cairo University children hospital /	Cai01.11.28.M.Sc.2019.Yo.R Retrospective study of autoimmune uveitis : Presentations and prognosis /	Next

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background&Objectives:Hematopoietic stem cell transplantation (HSCT) offers potentially curative treatmnt for bone marrow failure syndromes (BMFS). We aimed to evaluate the BMFS-free survival and outcome of stem cell transplantation in the Egyptian experience and to analyze the patients and donors{u2019} characteristics as well as transplantation related factors that could affect the graft success rate. Methods: This study retrospectively analyzed 147 patients who underwent stem cell transplantation for BMFS (congenital or acquired) in Nasser institute, between January 2009 and December 2015.Results: Patients{u2019} age at the time of transplantation ranged from 1.0 to 18.0 years; with a mean of10.5±4.9 and median 10 years. Ninety four were males (M/F ratio: 1.7). Out of the 147 patients; 10 (6.8%) patients received bone marrow and 137(93.2%) received peripheral blood stem cells (PBSC) harvest. All donors were HLA identical with 137 matched sibling donors and 10 matched parent donors. Transplant related mortality was 23.8% and the most common cause of death was infection in 57.1% of cases.The probabilities of 5- year overall survival (OS) was 73.4%,disease free survival (DFS) was 74.2 % andevent free survival (EFS) was 70.4%. OS and DFS were significantly worse in patients who had aGVHD (p=0.001, 0.001 respectively)

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer