Performance of nanohydroxapatite in overcoming the acute renal failure induced by cisplatin in male rats / Maha Mohammed Farid Ahmed ; Supervised Elsayed Fahim Elsayed Taha , Eman Ismaiel Abdelgawad
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TextLanguage: English Publication details: Cairo : Maha Mohammed Farid Ahmed , 2020Description: 109 P. : charts , facsimiles ; 25cmOther title: - أداء النانوهيدروكسى أباتيت فى التغلب على الفشل الكلوى الحاد الناجم عن السيسبلاتين فى ذكور الجرذان [Added title page title]
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Thesis
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.21.M.Sc.2020.Ma.P (Browse shelf(Opens below)) | Not for loan | 01010110080731000 | ||
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.21.M.Sc.2020.Ma.P (Browse shelf(Opens below)) | 80731.CD | Not for loan | 01020110080731000 |
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Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
A population of rats was divided into four groups: Group1 injected intrapretioneal with saline, Group2 injected intravenously weekly with 100 mg/kg b.w. for three weeks, Group3 injected i.p. once with 5 mg/kg b.w. CDDP and Group4 received CDDP plus nano-HAp. In tissues, DNA fragmentation, kim 1 and histopathological were performed. In serum, NGAL,TNF-Ü, MCP-1, IL-10, BUN, creatinine, Na and K were measured.The results revealed that uptake of CDDP caused acute kidney injury.The treatment with nano-HAp repaired efficiently the fragmented DNA and ameliorated the most of investigated parameters.The histopathological observation was in agreement with biochemical results.In conclusion, nano-HAp succeeded in handling the symptoms of AKI and produced a new hope for patients to get treatment safe, fast and effective
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