Toxicity study of iron oxide magnetic nanoparticles in wistar rats / Esraa Mohsen Aly Youseff ; Supervised Anwar Abdelazim Aly Elsayed , Neveen Amin Noor , Heba Mohamed Fahmy
Material type:
TextLanguage: English Publication details: Cairo : Esraa Mohsen Aly Youseff , 2020Description: 108 P. : charts , facsimiles ; 25cmOther title: - دراسة سمية الجسيمات النانوية المغناطيسية لأكسيد الحديد فى جرذان ويستار [Added title page title]
- Issued also as CD
| Item type | Current library | Home library | Call number | Copy number | Status | Barcode | |
|---|---|---|---|---|---|---|---|
Thesis
|
قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.04.M.Sc.2020.Es.T (Browse shelf(Opens below)) | Not for loan | 01010110081351000 | ||
CD - Rom
|
مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.04.M.Sc.2020.Es.T (Browse shelf(Opens below)) | 81351.CD | Not for loan | 01020110081351000 |
Browsing المكتبة المركزبة الجديدة - جامعة القاهرة shelves Close shelf browser (Hides shelf browser)
| No cover image available | No cover image available | No cover image available | No cover image available | No cover image available | No cover image available | No cover image available | ||
| Cai01.12.04.M.Sc.2020.Al.E Electric field effect on the aquatic insects / | Cai01.12.04.M.Sc.2020.As.T Treatment of anemia using nanoparticles / | Cai01.12.04.M.Sc.2020.As.T Treatment of anemia using nanoparticles / | Cai01.12.04.M.Sc.2020.Es.T Toxicity study of iron oxide magnetic nanoparticles in wistar rats / | Cai01.12.04.M.Sc.2020.Es.T Toxicity study of iron oxide magnetic nanoparticles in wistar rats / | Cai01.12.04.M.Sc.2020.Fa.B A biophysical approach for the optimization of mesoporous silica nanoparticles / | Cai01.12.04.M.Sc.2020.Fa.B A biophysical approach for the optimization of mesoporous silica nanoparticles / |
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics
The expansion of researches about magnetic iron oxide nanoparticles (MIONs) involved in several applications, especially in biomedicine and neurobiology urged to evaluate their possible toxicity. So, the aim of this study was to evaluate toxicity of MIONs which were synthesized using a carob leaf extract on various brain areas of Wistar rats. The MIONs were characterized using different techniques: Dynamic Light Scattering (DLS),Transmission Electron Microscope (TEM), UV-Vis spectrophotometer, Fourier Transform infrared (FTIR) spectroscopy, X-Ray Diffraction (XRD) and Atomic Force Microscope (AFM). The toxicity of MIONs in vivo was evaluated by: monitoring rats{u2019} body weight, measuring iron content in different brain areas, estimation of some oxidative stress parameters (Malondialdehyde (MDA), reduced glutathione (GSH), Nitric oxide (NO)), Acetylcholinesterase (AChE) activity, and Histopathological investigations. TEM images and topographic images of AFM demonstrated the spherical shape of MIONs. The size of particles was determined by using TEM and it was 15.63±2.38 nm, while the hydrodynamic diameter of particles was 80.18 ± 23.01 nm as obtained from dynamic light scattering technique.The stability of MIONs was confirmed by measuring zeta potential of particles which was -26.0 ± 2.55 mV. UV-Vis spectrum, FTIR analysis and XRD verified the successful synthesis of MIONs. AFM demonstrated the rough surface of MIONs
Issued also as CD
There are no comments on this title.
Click on an image to view it in the image viewer