Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Surgery- Anesthesiology and Radiology

This study was conducted to verify the effect of Poly lactic acid as optimal scaffold for enhancing healing of critical sized bone defect in dogs as an experimental model.Critical sized defect represents a major challenge in orthopedic surgery. PLA biopolymer has captured the most attention and interest as a bone tissue engineering material since PLA is easily processable and degrades and disintegrates into natural metabolites while its degradation rate matches with the healing time of damaged bone tissues.PLA biopolymer can be used for bone regeneration not only due to its akin mechanical characteristics to the targeted tissue, but also owing to its good biological interactions with the host cells when it is implanted.The aim of the present study was evaluating PLA with some additive on the healing of the critical sized bone defect in dogs

Issued also as CD