Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Orthopedics Surgery

The anterior cruciate ligament (ACL) is commonly injured and frequently reconstructed. Modern intra-articular reconstructive techniques produce clinically stable ligament reconstruction in the majority of cases; however, graft tears after reconstruction continue to be a problem.The use of allograft tissue in ACL reconstruction have been associated with increased graft failure rates. Platelet rich plasma (PRP) is a preparation of autologous platelets and plasma that are concentrated to a level greater than their naturally occurring levels in blood. PRP is typically prepared by centrifuging anti-coagulated autologous blood. When platelets are activated, they release numerous growth factors that have been shown to enhance tissue healing.These preparations have been shown in cell cultures to enhance fibrocyte growth and collagen production. Animal studies have demonstrated positive effects of PRP on collagen healing.The purpose of this study was to report and review the surgical technique and the clinical outcome of PRP in ACL reconstruction and compare with another control group without PRP. Between March 2014 and November 2016, 90 patients were enrolled in our study, Patients were divided into two groups; Group 1 (PRP group) Comprised 45 patients with ACL reconstruction and platelet-enriched PLASMA gel. Group2 (control group) Comprised 45 patients with ACL reconstruction without PRP. The study design was prospective comparative, randomized, controlled study and the results of the operations were monitored by an independent MRI expert in a blinded fashion with the agreement of the ethics committee

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