Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Operative Dentistry

The aim of this study was to compare in vivo the efficacy of polishing paste containing either 5% NovaMin or nano-hydroxy apatite, and a non-desensitizing polishing paste, on dentin hypersensitivity in a four-week, double-blind clinical study Methods: This was a randomized, single-center, controlled, three treatment, parallel- group study conducted at faculty of dentistry Cairo University .155 Male and female subjects who met all inclusion/exclusion criteria and had at least two sensitive teeth based on tactile , air blast and cold assessments, were enrolled in the study. At baseline, tactile air blast and cold stimuli were administered and subjects were stratified according to their diagnosis scores into one of three treatment groups: Group D1 (placebo paste), Group D2 (NovaMin without fluoride) or Group D3 (Nano-hydroxy apatite). Subjects were then assessed post-treatment at bassline (T1), 2 weeks (T2) and 4 weeks (T3), VAS was taken before and after materials application at the three time intervals participants were instructed not to use other oral hygiene products or any other dental treatment for hypersensitive teeth, and drugs like analgesics that may alter the pain perception within 24 hrs of the assessment days. Participants were instructed not to use any tooth paste that may ulter the results only brushing teeth with water without tooth paste.Results: A statistically significant difference was found between (D1) and each of (D2) and (D3) groups in all three tests where (p<0.001).The lowest mean value of pain score was found in Nano-hydroxy apatite (D3) followed by Novamin (D2) ,while the highest mean value of pain score was found in Placebo (D1). Also, a statistically significant difference was found between (Base-line) and each of (After 2 weeks) and (After 4 weeks) groups where (p<0.001) and a statistically significant difference was found between (After 2 weeks) and (After 4 weeks) where (p<0.001) in all tactile, air and cold tests

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