Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics

Objective: To compare the therapeutic efficacy of prostaglandins when they are used alone versus a combination therapy of two types of prostaglandins to induce cervical ripening and effacement for induction of the second trimester missed abortion and occurrence of fetal expulsion. Methods: A Randomized clinical trial study in which 70 mid trimester trimester (13-28 weeks) missed abortion pregnant women admitted for medical induction of abortion, were randomly divided into two group (35 patients in each ). One group received only vaginal Misoprostol and the other group received dinoprostone (PGE2) priming followed by misoprostol.To determine the efficacy in form of " induction abortion interval ": the duration interval between the beginning of the induction and the complete expulsion of the abortus and also the number of the doses of misoprostol needed to complete expulsion. Results: It was proved in the study that combination between misoprostol and dinoprostone gives at least the same effect as misoprostol when used alone regarding cervical consistency improvement, cervical dilatation, effacement, the whole induction time with less number of misoprostol doses needed to complete expulsion when compared to misoprostol alone and also fewer side effects as abdominal painbut we can get a benefit from combining both misoprostol and dinoprostone with fewer side effects

Issued also as CD