Docking Simulation, anticancer activities, and molecular studies on some enone derivatives / Ghada Khaled Abdullah Abdulrahman ; Suervised Ismail Abdelshafy Abdelhamid , Ahmed Helmy M. Elwahy , Sherif Abdelaziz Ibrahim
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TextLanguage: English Publication details: Cairo : Ghada Khaled Abdullah Abdulrahman , 2021Description: 81 P. : charts , facsimiles ; 25cmOther title: - التنميط الجزيئى ، نشاطات مضادة للسرطان و دراسات جزيئية على بعض مشتقات الاينون [Added title page title]
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Thesis
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.02.M.Sc.2021.Gh.D (Browse shelf(Opens below)) | Not for loan | 01010110085485000 | ||
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.12.02.M.Sc.2021.Gh.D (Browse shelf(Opens below)) | 85485.CD | Not for loan | 01020110085485000 |
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| Cai01.12.02.M.Sc.2021.Ay.B Biochemical studies on the production of extracellular xylanase from some locally isolated marine bacteria / | Cai01.12.02.M.Sc.2021.Ba.B Biosynthesis, characterization and application of metallic nanoparticles / | Cai01.12.02.M.Sc.2021.Ba.B Biosynthesis, characterization and application of metallic nanoparticles / | Cai01.12.02.M.Sc.2021.Gh.D Docking Simulation, anticancer activities, and molecular studies on some enone derivatives / | Cai01.12.02.M.Sc.2021.Gh.D Docking Simulation, anticancer activities, and molecular studies on some enone derivatives / | Cai01.12.02.M.Sc.2021.Kh.U Use of ⁵⁵Mn (n, Þ)⁵⁶ Mn reaction in standard neutron dosimetry / | Cai01.12.02.M.Sc.2021.Kh.U Use of ⁵⁵Mn (n, Þ)⁵⁶ Mn reaction in standard neutron dosimetry / |
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
A series of bis-chalcones with alkyl linkers incorporating 3-(thiophen-2-yl)pyrazole 5-10 has been prepared by the condensation reaction of two moles of 3-(thiophen-2-yl)pyrazole-4-aldehyde 4 with one mole of bis- o- or p-(acetophenones) 3a-f. The synthesized compounds 5-10 have been fully characterized and tested as novel anti-cancer agents. The in vitro anticancer activity of the compounds 5-10 was evaluated against a panel of human cancer cell lines (A431, A549, and PC3), and a normal human skin fibroblast BJ1. Compound 10 was the most promising in the prepared series with IC50 (48.7 and 74.2 og/mL) against epidermoid cancer cell line A431 and the lung adenocarcinoma cell line A549, respectively, compared to the reference drug doxorubicin (IC50, 28.3 and 27.9 og/mL, respectively).The target compound 10 was investigated theoretically using molecular docking study to different domain sets (1dls, 2c6o, 2w3t, 4kmn, and 4wt2) and they illustrated different modes of action with different binding energies
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