Thesis (Ph.D.) - Cairo University - Faculty of National Institute of Laser Enhanced Science - Department of Laser Applications in Dermatology

The treatment of acne remains a challenge for dermatologists. A variety of conventional therapies are available for acne. Treatment such as topical and systemic medications. Although many of these traditional acne treatments are effective, the wide-spread nature of the disease and its sometimes-resistant nature delineate the need for alternative therapies. Therefore, over the past decade, phototherapy has been introduced for the treatment of acne, such as pulsed dye lasers (PDLs) and photodynamic therapy (PDT). The aim of this study was to compare the safety and efficacy of PDL and methylene blue-mediated photodynamic therapy (MB-PDT) in two different vehicles for the treatment of mild to moderate acne. A split-face clinical trial including thirty patients presenting with mild to moderate acne were treated with 585 nm PDL on the right side of the face and MB-PDT with 665 nm diode laser on the left side was conducted. The photosensitizer MB was prepared in nanoemulgel formulation and Penetration enhancer vesicles (PEVs), the treatment was carried out for three sessions maximum at 2-weeks intervals.

Issued also as CD