Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Gynecology and Obstetrics

Abnormal uterine bleeding is one of the most frequent gynecologic problemsAbnormal uterine bleeding may involve any disturbance of regularity , frequency , duration or volume of menstrual flow80in hundred of abnormal uterine bleeding are due to hormonal disorders , called dysfunctional uterine bleeding , the others are of organic causesDisorders of the female genital tract caused by endocrine disturbances commonly lead to two presenting complaints : Dysfunctional uterine bleeding and infertilitySecondary ovarian dysfunction may be caused by hypothalamic - pituitary dysergulation , hyperprolactinemia , thyroid disorders and hyperandrogenemiaThis study showed that there were significant increase in serum total T3 , free T3 and total T4 and significant decrease in serum TSH hormone among the group of menorrhgia when compared to both oligo - hypomenorrhea and control groupsFrom the results of the present study we can conclude that impaired thyroid function plays an intimate role on the hypothalamic - pituitary - ovarian axis and this is reflected as dysfunctional uterine bleedingIt is highly recommended to add thyroid function tests as a routine in all cases of dysfunctional uterine bleeding

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