Gehan Hamed Shahin <br/><br/>
Expression of JAK2 V617F mutation in chronic myeloproliferative disorders /  
 التعبير عن طفرة جاك 2 فى 617 اف فى امراض التكاثر الميلويدى المزمن 
Gehan Hamed Shahin ; Supervised Sherif Nasseh Amin , Samah Mohamed Abdelhameed , Manal Mohamed Mahmoud Makhlouf 
 - Cairo :   Gehan Hamed Shahin ,   2008 
 - 181P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology 
<br/><br/> JAK2 is a non receptor tyrosine kinase that plays a major role in myeloid development by transducing signals from diverse cytokines and growth factor receptors a mutation in this janus kinase interferes with the negative regulation of JAK2 and could account for the hypersensitivity of myeloid cells from MPD patients to growth factors 
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<br/><br/><label>Subjects--Index Terms: </label>CMPDs patients JAK2 V617F MPD