TY - GEN AU - Gehan Hamed Shahin AU - Manal Mohamed Mahmoud Makhlouf , AU - Samah Mohamed Abdelhameed , AU - Sherif Nasseh Amin , TI - Expression of JAK2 V617F mutation in chronic myeloproliferative disorders / PY - 2008/// CY - Cairo : PB - Gehan Hamed Shahin , KW - CMPDs patients KW - JAK2 V617F KW - MPD N1 - Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology; Issued also as CD N2 - JAK2 is a non receptor tyrosine kinase that plays a major role in myeloid development by transducing signals from diverse cytokines and growth factor receptors a mutation in this janus kinase interferes with the negative regulation of JAK2 and could account for the hypersensitivity of myeloid cells from MPD patients to growth factors UR - http://172.23.153.220/th.pdf ER -