P53 dysfunction in chronic lymphocytic leukemia /
الإضطراب الوظيفى للعامل ب53 فى مرض سرطان الدم الليمفاوى المزمن
Rabab Afifi Mohamed ; Supervised Amr Hammam Zeyada , Osaman Mohamed Mansour , Sonya Fahmy Arsanyos
- Cairo : Rabab Afifi Mohamed , 2007
- 193 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology
The aim of this study was to determine p53 dysfunction in CLL patients.In response to chemotherapy as detected by impaired up regulation of p53 and p21 in response to chemotherapy.Determine it p53 dysfunction was caused by Mdm2 over expression