TY - BOOK AU - Hanan Maged Labib, AU - Rafat Milad Mohareb AU - Refaat Ibrahim Naseem TI - The use of β-diketone and cyanomethylene reagents for the synthesis of heterocyclic compounds and their fused derivatives with anti-tumor activities U1 - 547.59 PY - 2024/// KW - Heterocyclic compounds KW - qrmak KW - B-diketone KW - cyanomethylene KW - Gewald’s thiophene synthesis KW - anti-tumor activity N1 - Thesis (Ph.D)-Cairo University, 2024; Bibliography: pages 201-218; Issues also as CD N2 - In this thesis we worked on synthesizing new heterocyclic compounds using B-diketones and cyanomethylene reagents. The synthetic schemes involved multicomponent reactions. Gewald’s thiophene synthesis was also involved to produce biologically active fused thiophene compounds. Anti-proliferative evaluations and inhibitions for the new synthesized compounds and their fused derivatives towards selected cancer cell lines were carried out along with foretinib as the positive control. The results revealed that many of the new compounds have high inhibition. This opens the way for more research especially in the drugs synthesis field; ﻓﻲ ھﺬه اﻟﺮﺳﺎﻟﺔ، ﻗﻤﻨﺎ ﺑﺘﺤﻀﯿﺮ ﻣﺮﻛﺒﺎت ﻏﯿﺮ ﻣﺘﺠﺎﻧﺴﺔ اﻟﺤﻠﻘﺔ ﺑﺎﺳﺘﺨﺪام اﻟﺒﯿﺘﺎ ﺛﻨﺎﺋﻲ اﻟﻜﯿﺘﻮن و اﻟﺴﯿﺎﻧﻮﻣﯿﺜﯿﻠﯿﻦ. ﺗﻀﻤﻨﺖ اﻟﻤﺨﻄﻄﺎت ﺗﻔﺎﻋﻼت ﻣﺘﻌﺪدة اﻟﻤﻜﻮﻧﺎت.اﯾﻀﺎ ﺗﻢ اﺳﺘﺨﺪام ﺗﻔﺎﻋﻞ Gewald’s ﻟﺘﺤﻀﯿﺮ ﻣﺮﻛﺒﺎت اﻟﺜﯿﻮﻓﯿﻦ اﻟﻨﺸﻄﺔ. ﺗﻢ ﺗﻘﯿﯿﻢ اﻟﻨﺸﺎط اﻟﻤﻀﺎد ﻟﻠﺘﻜﺎﺛﺮ و اﻟﺘﺜﺒﯿﻂ ﻟﻠﻤﺮﻛﺒﺎت اﻟﻤﺼﻨﻌﺔ ﺣﺪﯾﺜﺎ و ﻣﺸﺘﻘﺎﺗﮭﺎ ﻣﻘﺎﺑﻞ ﺧﻄﻮط اﻟﺨﻼﯾﺎ اﻟﺴﺮطﺎﻧﯿﺔ ﺟﻨﺒﺎ اﻟﻲ ﺟﻨﺐ ﻣﻊ foretinib ﻛﻌﻨﺼﺮ ﺗﺤﻜﻢ اﯾﺠﺎﺑﻲ. اظﮭﺮت اﻟﻨﺘﺎﺋﺞ ان اﻟﻤﺮﻛﺒﺎت ﻟﺪﯾﮭﺎ ﺗﺜﺒﯿﻂ ﻋﺎﻟﻲ. ھﺬا ﯾﻔﺘﺢ اﻟﻄﺮﯾﻖ ﻟﻤﺰﯾﺪ ﻣﻦ اﻟﺒﺤﺚ ﺧﺎﺻﺔ ﻓﻲ ﻣﺠﺎل ﺻﻨﺎﻋﺔ اﻟﺪواء ER -