TY  - BOOK
AU  - Ghada Mohamed Mohamed Ahmed Khalil,
AU  - Safaa Y. S. Ahmed
AU  - Shaymaa I. Salem
AU  - Khaled M. A. Mahran
AU  - Mohamed E. Ali 
TI  - Clinicopathological studies on some novel renal biomarkers in cats
U1  - 636.8 
PY  - 2024///
KW  - Cats
KW  - SDMA
KW  - urinalysis
KW  - THP
KW  - NAG
KW  - KIM-1
N1  - Thesis (Ph.D)-Cairo University, 2024; Bibliography: pages 74-97; Issues also as CD
N2  - Renal diseases are common disorders of felines, considered a leading death 
cause, and exhibit a diagnostic challenge due to a shortage of early damage markers. 
The traditional biomarkers [e.g., serum creatinine (sCr) and blood urea nitrogen (BUN)] 
have low diagnostic sensitivity; thus, acute cases progress to chronic. This study aimed 
to clarify the clinicopathological, ultrasonographic, and pathological findings of cats 
affected with renal diseases, and the performance of novel renal biomarkers [symmetric 
dimethyl arginine (SDMA), kidney injury molecule-1 (KIM-1), Tamm-Horsfall protein 
(THP), and N-acetyl-β-D-glucosaminidase (NAG)] against the traditional ones. 
Furthermore, assessing the novel biomarker‟s role in the follow-up of treated cases. 86 
cats were allocated into 4 groups depending on clinical signs, physical examination, sCr 
concentration, and urine specific gravity (USG) as follows: I. Control negative group 
(15 apparently healthy cats), II. Control positive group (22 renal diseased cats), III. Pre-
azotemic group (31 cats), and IV. Diseased and treated group (18 treated cats). Blood 
and spot urine samples were collected from all groups. Blood samples for 
hematological, biochemical, arterial blood gas (ABG) analysis, as well as, SDMA, and 
KIM-1 concentrations. Spot urine samples for routine urinalysis, some biochemical 
parameters, NAG activity, and THP concentration. Groups II and III showed microcytic 
hypochromic anemia and significant leukopenia, significant increases in serum 
concentrations of SDMA, and KIM-1, and activity of urinary NAG; meanwhile, they 
showed a significant decrease in urinary THP concentration. Group IV after treatment 
revealed an improvement of all measured parameters except urinary THP concentration. 
In conclusion, the current study results found out that SDMA, KIM-1, and NAG could 
serve as efficient biomarkers of early renal injury detection and treatment follow-up.; تعتبر أمراض الكلى من أكثر المشكلات الطبية شيوعًا في القطط والتي تسبب خلل فسيولوجي وأيضي. العديد من الأسباب الفسيولوجية المرضية قد تتسبب في إحداثها من بينها الإصابة الحادة للكلي بالتلف والذي بدوره يؤدي إلى إنحدار سريع في وظائف الكلى وقد ينتهي بفشل مزمن في وظائف الكلى. يعنبر القط الحيوان الأكثر إصابة ووفاة من أمراض الكلى المزمنة من أي حيوان آخر خاصة القطط الكبيرة في السن بنسبة حدوث 80 %. 
الدلالات الحيوية هي جزيئات حيوية، غالبًا ما تكون بروتينات، تتأرجح (زيادة أو نقصان) نتيجة التغيرات المرضية. بدأ عصر جديد في مجال طب وأمراض الكلى مع ظهور الدلالات الحيوية الجديدة الخاصة بتلف الكلى، كما أنها طورت أولوية بحثية ترتبط بتحسين التشخيص والمتابعة والتكهن وصنع القرارات والأدوات الجديدة الخاصة بأمراض الكلى.
ER  -