Omnia Mostafa Fahmey Mohamed, <br/><br/>
Novel metal complexes derived from some transition metals and schiff bases :  synthesis, biological activity and analytical applications / 
 ﻣﺘﺮاﻛﺒﺎت ﻓـﻠﺰﻳﺔﺟﺪﻳﺪﻩ ﻣﺸﺘﻘﻪ ﻣﻦ ﺑﻌﺾ اﻟﻔـﻠﺰات اﻻﻧﺘﻘـﺎﻟﻴﻪ وﻗﻮاﻋﺪ ﺷﻴﻒ :   ﺗﺤﻀﻴﺮ واﻟﻨﺸﺎط اﻟﺒﻴﻮﻟﻮﺟﻰ واﻟﺘﻄﺒﻴﻘـﺎت اﻟﺘﺤﻠﻴﻠﻴﻪ /  
by Omnia Mostafa Fahmey Mohamed ; Supervised rof Dr. Rasha Mohamed El Nashar, Prof Dr. Ahmed Abdou El- Sherif. 
 - 73 pages :   illustrations ;  25 cm. +   CD. 
<br/><br/>Thesis (Ph.D)-Cairo University, 2024. 
<br/><br/>Bibliography: pages 19-24 
<br/><br/> A novel hydrazinyl Schiff base ligand derived from 1-hydrazinylphthalazine and 1-(2H- benzo[d][1,2,3]triazol-2-yl)propan-2-one was synthesized and used to prepare metal complexes with Co(II), Pd(II), and Cd(II). The Schiff base ligand and its complexes were comprehensively characterized using various spectroscopic and analytical techniques, including conductometry, elemental analysis, FT-IR, UV-Vis, 1H NMR, 13C NMR, TGA, and mass spectrometry. The metal complexes exhibited enhanced antimicrobial and anticancer activities compared to the free Schiff base ligand. The Co(II) and Cd(II) complexes were transformed into nanostructures for environmental applications. These nanostructure complexes were characterized using XRD, SEM, AFM, Zeta Potential, DLS, Contact Angle measurement, and BET surface area analysis. Nanostructured forms of the Co(II) and Cd(II) complexes were developed and applied as quartz crystal microbalance (QCM) sensors for the detection of arsenic and cadmium ions in aqueous media, respectively. The nanosensors demonstrated high sensitivity, with detection limits as low as 0.1 ppm for cadmium and 1 ppm for arsenic. The effects of pH, temperature, and analyte concentration on sensor performance were investigated. The nanoparticles demonstrated excellent colloidal stability, high surface area, and favorable hydrophobic properties. Cytotoxicity studies confirmed their biocompatibility. Molecular docking studies provided insights into the compounds' binding interactions with various biological targets. This research highlights the versatility of the novel Schiff base [(E)-1-(2-(1-(2H-benzo[d][1,2,3]triazol-2-yl)propan-2- ylidene)hydrazinyl)phthalazine] and its metal complexes for environmental monitoring and potential biomedical applications. The extensive experimental characterization, theoretical computations, and practical applications in environmental and biomedical fields lead to a comprehensive understanding of these new compounds. The findings open up opportunities for further exploration in areas such as environmental remediation, water quality monitoring, drug development, and biosensing technologies. There is a particular emphasis on the role of specific Metal-Schiff base combinations in modulating the properties and applications of these complexes.  ھﺬه اﻟﺪراﺳﺔ ﺗﺮﺗﻜﺰ ﻋﻠﻰ ﺗﺤﻀﯿﺮ ﻟﯿﺠﺎﻧﺪ ﻗﺎﻋﺪة ﺷﯿﻒ ھﯿﺪرازﯾﻨﯿﻞ اﻟﺠﺪﯾﺪه اﻟﻤﺸﺘﻘﮫ ﻣﻦ hydrazinylphthalazine) (1- و<br/><br/>(1-H-benzo[d][1,2,3]triazol-2-yl)propan-2-one2) واﺳﺘﺨﺪاﻣﮭﺎ ﻟﺘﺤﻀﯿﺮ اﻟﻤﺘﺮاﻛﺒﺎت اﻟﻤﻌﺪﻧﯿﺔ ﻣﻊ اﻟﻌﻨﺎﺻﺮ اﻻﻧﺘﻘﺎﻟﯿﮫ اﻟﺘﻰ ﺗﺸﻤﻞ<br/>ﻛﻼ ﻣﻦ اﻟﻜﺎدﻣﯿﻮم (Cd(II)) واﻟﺒﻼدﯾﻮم(pd(II)) واﻟﻜﻮﺑﻠﺖ (Co(II)) . ﺗﻢ ﺗﻮﺻﯿﻒ ﻗﺎﻋﺪة ﺷﯿﻒ اﻟﺠﺪﯾﺪه وﻣﺘﺮاﻛﺒﺎﺗﮭﺎ اﻟﻤﻌﺪﻧﯿﮫ<br/><br/>ﺑﺸﻜﻞ ﺷﺎﻣﻞ ﺑﺎﺳﺘﺨﺪام ﻣﺨﺘﻠﻒ اﻟﺘﻘﻨﯿﺎت اﻟﻄﯿﻔﯿﺔ واﻟﺘﺤﻠﯿﻠﯿﺔ، ﺑﻤﺎ ﻓﻲ ذﻟﻚ ﻗﯿﺎس اﻟﺘﻮﺻﯿﻞ، اﻟﺘﺤﻠﯿﻞ اﻟﻌﻨﺼﺮي، FT-IR، UV-Vis، NMR1 H، NMR13 C، TGA، وطﯿﻒ اﻟﻜﺘﻠﺔ spectrometry) (mass .أظﮭﺮت اﻟﻤﺘﺮاﻛﺒﺎت اﻟﻤﻌﺪﻧﯿﺔ ﻧﺸﺎطًﺎ ﻣﻀﺎدًا ﻟﻠﻤﯿﻜﺮوﺑﺎت وﻣﻀﺎدًا ﻟﻠﺴﺮطﺎن ﻣﻌﺰزا ﻣﻘﺎرﻧﺔً ﺑﺎﻟﯿﺠﻨﺪ ﻗﺎﻋﺪه ﺷﯿﻒ اﻟﺤﺮه. ﻟﻠﺘﻄﺒﯿﻘﺎت اﻟﺒﯿﺌﯿﺔ، ﺗﻢ ﺗﺤﻮﯾﻞ ﻣﺘﺮاﻛﺒﺎت اﻟﻜﻮﺑﻠﺖ واﻟﻜﺎدﻣﯿﻮم<br/>إﻟﻰ ﺑﻨﻰ ﻧﺎﻧﻮﯾﺔ. ﺗﻢ ﺗﻮﺻﯿﻒ ھﺬه اﻟﺒﻨﻰ اﻟﻨﺎﻧﻮﯾﺔ ﺑﺎﺳﺘﺨﺪامXRD ، SEM، AFM، ﺟﮭﺪ زﯾﺘﺎ potential) Zeta ( ، ﺗﺸﺘﺖ اﻟﻀﻮء<br/><br/> <br/>ﺗﻢ ﺗﻄﻮﯾﺮ اﻟﻤﺘﺮاﻛﺒﺎت ذات اﻟﺒﻨﯿﺔ اﻟﻨﺎﻧﻮﯾﺔ ﻟﻤﺘﺮاﻛﺒﺎت<br/> <br/>.(BET)<br/> <br/>اﻟﺪﯾﻨﺎﻣﯿﻜﻲ (DLS)، ﻗﯿﺎس زاوﯾﺔ اﻟﺘﻤﺎس، وﺗﺤﻠﯿﻞ ﻣﺴﺎﺣﺔ اﻟﺴﻄﺢ<br/> <br/>Co(II) وCd(II) وﺗﻄﺒﯿﻘﮭﺎ ﻛﻤﺴﺘﺸﻌﺮات (QCM) ﻟﻠﻜﺸﻒ ﻋﻦ أﯾﻮﻧﺎت اﻟﺰرﻧﯿﺦ واﻟﻜﺎدﻣﯿﻮم ﻓﻲ اﻻوﺳﺎط اﻟﻤﺎﺋﯿﺔ، ﻋﻠﻰ اﻟﺘﻮاﻟﻲ. أظﮭﺮت ﺗﻠﻚ اﻟﻤﺘﺮاﻛﺒﺎت اﻟﻨﺎﻧﻮﯾﺔ ﺛﺒﺎﺗًﺎ ﻏﺮوﯾًﺎ ﻣﻤﺘﺎزًا ، وﻣﺴﺎﺣﺔ ﺳﻄﺤﯿﺔ ﻋﺎﻟﯿﺔ، وﺧﺼﺎﺋﺺ ﻛﺎرھﺔ ﻟﻠﻤﺎء. أظﮭﺮت ﺗﻠﻚ اﻟﻤﺴﺘﺸﻌﺮات<br/>اﻟﻨﺎﻧﻮﯾﺔ ﺣﺴﺎﺳﯿﺔ ﻛﺸﻒ ﻋﺎﻟﯿﺔ، ﺗﺼﻞ إﻟﻰ 0.1 ﺟﺰء ﻓﻲ اﻟﻤﻠﯿﻮن ﻟﻠﻜﺎدﻣﯿﻮم و1 ﺟﺰء ﻓﻲ اﻟﻤﻠﯿﻮن ﻟﻠﺰرﻧﯿﺦ. ﺗﻤﺖ دراﺳﺔ ﺗﺄﺛﯿﺮات اﻟﺮﻗﻢ<br/><br/>اﻟﮭﯿﺪروﺟﯿﻨﻲ ودرﺟﺔ اﻟﺤﺮارة وﺗﺮﻛﯿﺰ اﻟﻤﺎدة اﻟﻤﺤﻠﻠﺔ ﻋﻠﻰ أداء ﺟﮭﺎز اﻻﺳﺘﺸﻌﺎر .(QCM) أﻛﺪت دراﺳﺎت اﻟﺴﻤﯿﺔ اﻟﺨﻠﻮﯾﺔ ﺗﻮاﻓﻘﮭﺎ<br/><br/>اﻟﺤﯿﻮي. ﻗﺪﻣﺖ دراﺳﺎت اﻹرﺳﺎء اﻟﺠﺰﯾﺌﻲ رؤى ﺣﻮل ﺗﻔﺎﻋﻼت ارﺗﺒﺎط ﺗﻠﻚ اﻟﻤﺘﺮاﻛﺒﺎت ﻣﻊ اھﺪاف ﺑﯿﻮﻟﻮﺟﯿﺔ ﻣﺘﻨﻮﻋﮫ. ﯾﺴﻠﻂ اﻟﺒﺤﺚ<br/><br/>اﻟﻀﻮء ﻋﻠﻰ اﻻﺳﺘﺨﺪاﻣﺎت اﻟﻤﺘﻌﺪده ﻟﻘﺎﻋﺪة ﺷﯿﻒ اﻟﺠﺪﯾﺪة [(E)-1-(2-(1-(2H-benzo[d][1,2,3]triazol-2-yl)propan-]<br/><br/>2-ylidene)hydrazinyl)phthalazine وﻣﺘﺮﻛﺒﺎﺗﮭﺎ اﻟﻔﻠﺰﯾﺔ ﻓﻲ اﻟﺮﺻﺪ اﻟﺒﯿﺌﻲ واﻟﺘﻄﺒﯿﻘﺎت اﻟﻄﺒﯿﺔ اﻟﺤﯿﻮﯾﺔ اﻟﻤﺤﺘﻤﻠﺔ. ﯾﺆدي<br/><br/>اﻟﺘﻮﺻﯿﻒ اﻟﺘﺠﺮﯾﺒﻲ اﻟﺸﺎﻣﻞ واﻟﺤﺴﺎﺑﺎت اﻟﻨﻈﺮﯾﺔ واﻟﺘﻄﺒﯿﻘﺎت اﻟﻌﻤﻠﯿﺔ ﻓﻲ اﻟﻤﺠﺎﻻت اﻟﺒﯿﺌﯿﺔ واﻟﻄﺒﯿﺔ اﻟﺤﯿﻮﯾﺔ إﻟﻰ ﻓﮭﻢ ﺷﺎﻣﻞ ﻟﮭﺬه<br/><br/>اﻟﻤﺘﺎرﻛﺒﺎت اﻟﺠﺪﯾﺪة. ﺗﻔﺘﺢ اﻟﻨﺘﺎﺋﺞ ﻓﺮﺻًﺎ ﻟﻤﺰﯾﺪ ﻣﻦ اﻻﺳﺘﻜﺸﺎف ﻓﻲ ﻣﺠﺎﻻت ﻣﺜﻞ اﻟﻤﻌﺎﻟﺠﺔ اﻟﺒﯿﺌﯿﺔ، وﻣﺮاﻗﺒﺔ ﺟﻮدة اﻟﻤﯿﺎه، وﺗﻄﻮﯾﺮ اﻷدوﯾﺔ، وﺗﻘﻨﯿﺎت اﻻﺳﺘﺸﻌﺎر اﻟﺤﯿﻮي. ھﻨﺎك ﺗﺮﻛﯿﺰ ﺧﺎص ﻋﻠﻰ دور ﻣﺘﺮاﻛﺒﺎت ﻣﻌﯿﻨﺔ ﻣﻦ اﻟﻤﻌﺎدن وﻗﻮاﻋﺪ ﺷﯿﻒ ﻓﻲ ﺗﻌﺪﯾﻞ ﺧﺼﺎﺋﺺ<br/>وﺗﻄﺒﯿﻘﺎت ھﺬه اﻟﻤﺘﺮاﻛﺒﺎت. 
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<br/><br/><br/>Text in English and abstract in Arabic & English. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Analytical Chemistry<br/>الكيمياء التحليلية 
<br/><br/><label>Subjects--Index Terms: </label>Schiff base  metal complexes  nanostructures  QCM sensors  heavy metal detection  antimicrobial activity  anticancer activity  molecular docking 
<br/><br/><label>Dewey Class. No.: </label>543