Rania Ahmed Salamma Mahgoub, <br/><br/>
Biochemical studies on food fortification with some vitamins and minerals for anemia treatment / 
 دراسات كيميائية حيوية على تزويد الغذاء ببعض الفيتامينات والمعادن لعلاج الانيمياء 
by Rania Ahmed Salamma Mahgoub ; Supervisors Dr. Abdel Kader Moursy Abdel-Samad, Dr.Mohamed Abdel-Moneam Naguib, Dr.Mahmoud Abdel-Haleim Mahmoud, Dr. Hanna Hussein El-Sayed. 
 - 178 pages :  illustrations ;   25 cm. +   CD. 
<br/><br/>Thesis (Ph.D)-Cairo University, 2024. 
<br/><br/>Bibliography: pages 156-178. 
<br/><br/> Iron deficiency anemia (IDA) represents a critical global health concern. This <br/>investigation involves the characterization and evaluation of several <br/>nanoparticle formulations—iron oxide magnetic nanoparticles (IONPs), zinc <br/>oxide nanoparticles (ZnO-NPs), magnesium oxide nanoparticles (MgO-NPs), <br/>and iron folate nanoparticles—as potential treatments for IDA. For the in vivo <br/>study, 110 Sprague-Dawley rats (both female and male) were divided into <br/>seven groups: a normal group, anemic rats, and four groups treated with <br/>various iron formulations. IDA was induced in the rats using an iron-deficient <br/>diet, followed by feeding with different iron compounds until their hemoglobin <br/>levels reached 12 g/dl. The rats were then placed on a normal diet for two <br/>weeks. Biological and hematological parameters were monitored throughout <br/>the treatment. Results indicated that all treated groups showed positive <br/>outcomes, achieving normal values. Notably, iron folate nanoparticles <br/>demonstrated superior bioavailability, with female rats showing 244.23% HRE <br/>ratio/day and 19.89% RBV HRE ratio/day, and male rats showing 155.02% <br/>HRE ratio/day and 16.63% RBV HRE ratio/day, outperforming other treatments. <br/>Histopathological analysis revealed persistent liver tissue damage in anemic <br/>rats treated with FeSO4 and IONPs, though FeMgO-NPs and iron folate <br/>nanoparticles showed better results. The spleen appeared normal across all <br/>repleted groups. These findings suggest that IONPs can enhance iron <br/>bioavailability for IDA treatment, though their efficacy is improved when <br/>combined with other metals to maximize benefits and reduce side effects   يمثل فقر الدم الناجم عن نقص الحديد مشكلة صحية عالمية بالغة الاهمية. يتضمن هذا البحث توصيف وتقييم بيولوجي للعديد من تركيبات جزيئات أكسيد الحديد النانوية في علاجات فقر الدم الناجم عن نقص الحديد. اشارت النتائج الى ان جميع المجموعات المعالجة حققت قيما طبيعية. والجدير بالذكر ان جزيئات حمض الفوليك النانوية أظهرت توافرا حيويا متفوقا. تشير هذه النتائج الى ان جزيئات أكسيد الحديد النانوية يمكن ان تعزز التوافر الحيوي للحديد لعلاج فقر الدم الناجم عن نقص الحديد وتتحسن فعاليتها عند دمجها مع معادن نانوية وحمض الفوليك كفيتامين لتحقيق اقصى قدر من الفوائد وتقليل الاثار الجانبية. 
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<br/><br/><br/>Text in English and abstract in Arabic & English. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Biochemistry<br/>الكيمياء الحيوية
<br/><br/><label>Subjects--Index Terms: </label>iron deficiency anemia  fortification  IONPs  nano  metals  folic acid 
<br/><br/><label>Dewey Class. No.: </label>572