Mohamed Kamal Abd El hamid <br/><br/>
Synthesis of Some Fused Pyrazine and Diazepine Derivatives of Biological Interest /  
 تحضير بعض مشتقات البيرازين والدايازابين الملتحمة ذات الاهمية البيولوجية 
Mohamed Kamal Abd El hamid ; Supervised Mohga Mohamed Badran , SamihaMohamed Ali Roshdy 
 - Cairo :   Nour Shafik Elgendy ,   2005 
 - 137P :   charts ;   30cm 
<br/><br/>Thesis (PH.D.) - Cairo University - Faculty Of Pharmacy - Department Of Organic Chemistry 
<br/><br/> A survey covering the main general methods used for the synthesis of pyrroloquinoxaline , pyrrolothienopyrazine and pyrrolothienodiazepine derivatives is presented A brief outline of basic pharmacology of serotonin (5 - hydroxytryptamine , 5 - HT) and also the medicinal importance of some fused pyrazine and diazepine is given The different methods of preparing the starting compounds , intermediates and the final compounds are thoroughly investigated Open field test was done to determine changes of animal behaviors and as screening for antipsychotic activity , thus it can be concluded that some of the test compounds showed central sedative effects and possible anti - anxiety activity 
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<br/><br/><label>Subjects--Index Terms: </label>antipsychotic activity pyrrolothienodiazepine pyrrolothienopyrazine sertonin