TY  - GEN
AU  - Mohamed Kamal Abd El hamid
AU  - Mohga Mohamed badran , 
AU  - Samiha Mohamed Ali Roshdy , 
TI  - Synthesis of Some Fused Pyrazine and Diazepine Derivatives of Biological Interest / 
PY  - 2005///
CY  - Cairo : 
PB  - Nour Shafik Elgendy , 
KW  - antipsychotic activity
KW  - pyrrolothienodiazepine
KW  - pyrrolothienopyrazine
KW  - sertonin
N1  - Thesis (PH.D.) - Cairo University - Faculty Of Pharmacy - Department Of Organic Chemistry; Issued also as CD
N2  - A survey covering the main general methods used for the synthesis of pyrroloquinoxaline , pyrrolothienopyrazine and pyrrolothienodiazepine derivatives is presented A brief outline of basic pharmacology of serotonin (5 - hydroxytryptamine , 5 - HT) and also the medicinal importance of some fused pyrazine and diazepine is given The different methods of preparing the starting compounds , intermediates and the final compounds are thoroughly investigated Open field test was done to determine changes of animal behaviors and as screening for antipsychotic activity , thus it can be concluded that some of the test compounds showed central sedative effects and possible anti - anxiety activity
UR  - http://172.23.153.220/th.pdf
ER  -