Mohamed Assem Omar Abdelfattah <br/><br/>
Design, synthesis and biological evaluation of novel 2 - oxopyridine and 2- iminopyridine derivatives as potential anticancer and phosphodiesterase inhibitors /  
 تصميم وتشييد وتقييم بيولوجى لبعض مشتقات الاكسوبيريدين والامينوبيريدين كمضادات للسرطان ومثبطات لانزيم فوسفودايستراز 
Mohamed Assem Omar Abdelfattah ; Supervised Ashraf H. Abadi , Dalal A. Abouelella 
 - Cairo :   Mohamed Assem Omar Abdelfattah ,   2009 
 - 119 Leaves :   charts ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Milrinone is a cyanopyridone derivative that has been introduced for the treatment of CHF . Its mechanism of action involves inhibition of PDE3, leading to elevation of cAMP increasing the entry of Ca++ ions into the cardiac tissues and hence increasing the contractility of the cardiac muscle . On the other hand recent studies showed that PDE3 and other PDEs are over - expressed in malignant tumors and the inhibition of such PDEs and consequent high levels of cAMP or cGMP or both may be associated with anticancer and apoptotic activities