TY  - BOOK
AU  - Mohamed Assem Omar Abdelfattah
AU  - Ashraf H. Abadi , 
AU  - Dalal Abdelrahman Abouelella , 
TI  - Design, synthesis and biological evaluation of novel 2 - oxopyridine and 2- iminopyridine derivatives as potential anticancer and phosphodiesterase inhibitors / 
PY  - 2009///
CY  - Cairo : 
PB  - Mohamed Assem Omar Abdelfattah , 
N1  - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
N2  - Milrinone is a cyanopyridone derivative that has been introduced for the treatment of CHF . Its mechanism of action involves inhibition of PDE3, leading to elevation of cAMP increasing the entry of Ca++ ions into the cardiac tissues and hence increasing the contractility of the cardiac muscle . On the other hand recent studies showed that PDE3 and other PDEs are over - expressed in malignant tumors and the inhibition of such PDEs and consequent high levels of cAMP or cGMP or both may be associated with anticancer and apoptotic activities
UR  - http://172.23.153.220/th.pdf
ER  -