TY - BOOK AU - Mohammad Abdelhalim Abdelnaby AU - Ashraf Mostafa Abadi , TI - Design synthesis and biological evaluation of novel B- Carboline derivatives as anticancer agents and phosphodiesterase inhibitors / PY - 2008/// CY - Cairo : PB - Mohammad Abdelhalim Abdelnaby , N1 - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry N2 - Tadalafil is B -carboline derivative that has been introduced to the market as a medication for the treatment of the MED . Its mechanism of action involves inhibition of PDE5 , Leading to elevation of cGMP , Vascular relaxation in the corpora cavernosa and penile erection during sexual stimulation UR - http://172.23.153.220/th.pdf ER -