Mona Elsayed Ali Hassan Aboutabl <br/><br/>
Pharmacological Study of Some Possible Interactions between Sildenafil and Amlodipine as hypertensive Agent in Experimental Animals /  
 دراسة فارماكولوجية لبعض التداخلات المحتمل حدوثها بين دواء سيلدنافيل واملوديبين كمخفض لضغط الدم المرتفع فى حيوانات التجارب 
Mona Elsayed Ali Hassan Aboutabl ; Supervised Sanaa Abd El baky Kenawy , Yousreya Ali Maklad , Mohammed Raafat Abdalla 
 - Cairo :   Mona Elsayed Ali Hassan Aboutabl ,   2006 
 - 221 P. :   ill ;   30cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology 
<br/><br/> The present study has been carried out to investigate the possible physiological , pathological and biochemical changes that may develop from co - administration of sildenafil and one of the third generation calcium antagonists , amlodipine , in experimentally NZ - nitro - L - arginine methyl ester (L - NAME) induced hypertensive ratsIn order to achieve the goal of the present study , systolic blood pressure and heart rate were measured in normotensive , as well as L - NAMEinduced hypertensive rats. Treatment of hypertensive rats with sildenafil , amlodipine and their combination was also carried outThe relation of this complex model of hypertension to the biochemical changes was investigated by estimation of plasma NO metabolites (nitrate+nitrite) , as well as cGMP levels so as to highlight the possible derangement in the NO / cGMP pathway 
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<br/><br/><label>Subjects--Index Terms: </label>Amlodipine Histopathological Sildenafil