Mohamed Saleh Mohamed Ali <br/><br/>
Design synthesis and biological evaluation of novel tetrahydro - Ý - carboline derivatives as phosphodiesterase 5 inhibitors /  
 تصميم وتشييد بعض مشتقات البيتاكربولين وتقييمها بيولوجيا كمثبطات لإنزيم الفسفودايستراز5 
Mohamed Saleh Mohamed Ali ; Supervised Ashraf H. Abadi 
 - Cairo :   Mohamed Saleh Mohamed Ali ,   2009 
 - 94 P. :   facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Science in Organic Chemistry 
<br/><br/> PDE5 inhibitors is a large class of compounds that are primarily used to treat erectile dysfunction (MED) as well as having other medical applications . Tadalafil is one of the most potent members among this class despite its efficacy in treatment of MED it only exhibits a modest selectivity of 5 - folds for PDE - 5 compareed PDE - 11 which may be involved in sperm formation motility and\ or other homonal functions