TY - BOOK AU - Mary Eskander Attia AU - Ahmed Hussein Galal , AU - Amani Nabil Shafik , AU - Hisham Attia Awad , TI - Cardiovascular effects of ivabradine on induced myocardial ischemia in rats / PY - 2010/// CY - Cairo : PB - Mary Eskander Attia , KW - Heart rate KW - Ivabradine KW - Reperfusion N1 - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology; Issued also as CD N2 - Heart rate is a major determinant of oxygen consumption and metabolic demand . Higher heart rate many induce or exacerbate ischemia and symptoms of angina that is why rate - slowing drugs are considered to be the cornerstone of antianginal therapy . Reperfusion strategies are required to resuscitate the ischemic myocardium . However, reperfusion has the potential to exacerbate lethal tissue injury, a process termed reperfusion injury UR - http://172.23.153.220/th.pdf ER -