Yasmin Ahmed Salem Elfeky <br/><br/>
Formulation and evaluation of anti - migraine bioadhesive buccal preparations /  
 صياغة وتقييم مسحضرات لاصقة بأغشية الفم لعلاج الصداع النصفى 
Yasmin Ahmed Salem Elfeky ; Supervised Nabaweya Abdelaziz , Nagia Nagib Afifi , Eman Ibrahim Soliman 
 - Cairo :   Yasmin Ahmed Salem Elfeky ,   2011 
 - 241P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics 
<br/><br/> Sumatriptan succinate is the prototype is the prototype of the triptans, a family of abortive agents that resemble serotonin (a brain chemical active in migraine) act rapidly and are effective for many patients having migraine .Sumatriptan is rapidly but incompletely absorbed when given orally and undergoes first - pass metabolism, resulting in a low absolute bioavailability of about 14 % peak plasma concentrations following oral does are achieved in about 2 hours . The elimination half - life of sumatriptan is about 2 hours 
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<br/><br/><label>Subjects--Index Terms: </label>Buccal bioadhesive Buccoadhesive disc  Sumatriptan succinate