TY - BOOK AU - Yasmin Ahmed Salem Elfeky AU - Eman Ibrahim Soliman , AU - Nabaweya Abdelaziz , AU - Nagia Nagib Afifi , TI - Formulation and evaluation of anti - migraine bioadhesive buccal preparations / PY - 2011/// CY - Cairo : PB - Yasmin Ahmed Salem Elfeky , KW - Buccal bioadhesive KW - Buccoadhesive disc KW - Sumatriptan succinate N1 - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD N2 - Sumatriptan succinate is the prototype is the prototype of the triptans, a family of abortive agents that resemble serotonin (a brain chemical active in migraine) act rapidly and are effective for many patients having migraine .Sumatriptan is rapidly but incompletely absorbed when given orally and undergoes first - pass metabolism, resulting in a low absolute bioavailability of about 14 % peak plasma concentrations following oral does are achieved in about 2 hours . The elimination half - life of sumatriptan is about 2 hours UR - http://172.23.153.220/th.pdf ER -