TY - BOOK AU - Ibrahim Salah Ibrahim AU - Mahmoud Mohamed Ghorab , TI - Pharmaceutical and bio pharmaceutical studies on menindione in different dosage forms / PY - 2012/// CY - Cairo : PB - Ibrahim Salah Ibrahim , KW - B-cyclodextrin KW - Menindione KW - Phytomenadione N1 - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD N2 - Phytomenadione is a procoagulant factor. As a component of a hepatic carboxylase system. Phytomenadione is involved in carboxylation of clotting factors II (prothrombin). VII , IX and X , and of clotting inhibitors protein C and protein S in the postribosmal phase. Coumarins inhibit the reduction of Phytomenadione (quinone form) to Phytomenadione hydroquinone and also prevent the phytomenadione epoxide arising after the carboxylation reaction from being reduced to the quinone form UR - http://172.23.153.220/th.pdf ER -